Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/176852
Title: 5-Hydroxytryptamine, Glutamate, and ATP: Much More Than Neurotransmitters
Author: Franco Fernández, Rafael
Rivas Santisteban, Rafael
Lillo, Jaume
Camps, Jordi
Navarro Brugal, Gemma
Reyes Resina, Irene
Keywords: Serotonina
Adenosina
Serotonin
Adenosine
Issue Date: 15-Apr-2021
Publisher: Frontiers Media
Abstract: 5-hydroxytryptamine (5-HT) is derived from the essential amino acid L-tryptophan. Although the compound has been studied extensively for its neuronal handling and synaptic actions, serotonin 5-HT receptors can be found extra-synaptically and not only in neurons but in many types of mammalian cells, inside and outside the central nervous system (CNS). In sharp contrast, glutamate (Glu) and ATP are better known as metabolism-related molecules, but they also are neurotransmitters, and their receptors are expressed on almost any type of cell inside and outside the nervous system. Whereas 5-hydroxytryptamine and Glu are key regulators of the immune system, ATP actions are more general. 5-hydroxytryptamine, ATP and Glu act through both G protein-coupled receptors (GPCRs), and ionotropic receptors, i.e., ligand gated ion channels. These are the three examples of neurotransmitters whose actions as holistic regulatory molecules are briefly put into perspective here.
Note: Reproducció del document publicat a: https://doi.org/10.3389/fcell.2021.667815
It is part of: Frontiers In Cell And Developmental Biology, 2021, vol. 9, num. 667815
URI: http://hdl.handle.net/2445/176852
Related resource: https://doi.org/10.3389/fcell.2021.667815
ISSN: 2296-634X
Appears in Collections:Articles publicats en revistes (Bioquímica i Fisiologia)

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