Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/176854
Title: Potential of microfluidics and lab-on-chip platforms to improve understanding of 'prion-like' protein assembly and behavior
Author: Río Fernández, José Antonio del
Ferrer, Isidro (Ferrer Abizanda)
Keywords: Envelliment
Microfluídica
Aging
Microfluidics
Issue Date: 8-Sep-2020
Publisher: Frontiers Media
Abstract: Human aging is accompanied by a relevant increase in age-associated chronic pathologies, including neurodegenerative and metabolic diseases. The appearance and evolution of numerous neurodegenerative diseases is paralleled by the appearance of intracellular and extracellular accumulation of misfolded proteins in affected brains. In addition, recent evidence suggests that most of these amyloid proteins can behave and propagate among neural cells similarly to infective prions. In order to improve understanding of the seeding and spreading processes of these 'prion-like' amyloids, microfluidics and 3D lab-on-chip approaches have been developed as highly valuable tools. These techniques allow us to monitor changes in cellular and molecular processes responsible for amyloid seeding and cell spreading and their parallel effects in neural physiology. Their compatibility with new optical and biochemical techniques and their relative availability have increased interest in them and in their use in numerous laboratories. In addition, recent advances in stem cell research in combination with microfluidic platforms have opened new humanized in vitro models for myriad neurodegenerative diseases affecting different cellular targets of the vascular, muscular, and nervous systems, and glial cells. These new platforms help reduce the use of animal experimentation. They are more reproducible and represent a potential alternative to classical approaches to understanding neurodegeneration. In this review, we summarize recent progress in neurobiological research in 'prion-like' protein using microfluidic and 3D lab-on-chip approaches. These approaches are driven by various fields, including chemistry, biochemistry, and cell biology, and they serve to facilitate the development of more precise human brain models for basic mechanistic studies of cell-to-cell interactions and drug discovery.
Note: Reproducció del document publicat a: https://doi.org/10.3389/fbioe.2020.570692
It is part of: Frontiers In Bioengineering And Biotechnology, 2020, vol. 8, num. 570692
URI: http://hdl.handle.net/2445/176854
Related resource: https://doi.org/10.3389/fbioe.2020.570692
ISSN: 2296-4185
Appears in Collections:Articles publicats en revistes (Institut de Bioenginyeria de Catalunya (IBEC))
Articles publicats en revistes (Biologia Cel·lular, Fisiologia i Immunologia)
Articles publicats en revistes (Institut de Neurociències (UBNeuro))
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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