Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/176893
Full metadata record
DC FieldValueLanguage
dc.contributor.authorLong, Yun Chau-
dc.contributor.authorGlund, Stephan-
dc.contributor.authorGarcía-Roves, Pablo M. (Pablo Miguel)-
dc.contributor.authorZierath, Juleen R.-
dc.date.accessioned2021-04-29T10:38:10Z-
dc.date.available2021-04-29T10:38:10Z-
dc.date.issued2007-01-19-
dc.identifier.issn0021-9258-
dc.identifier.urihttp://hdl.handle.net/2445/176893-
dc.description.abstractThe metabolic property of skeletal muscle adapts in response to an increased physiological demand by altering substrate utilization and gene expression. The calcium-regulated serine/threonine protein phosphatase calcineurin has been implicated in the transduction of motor neuron signals to alter gene expression programs in skeletal muscle. We utilized transgenic mice that overexpress an activated form of calcineurin in skeletal muscle (MCK-CnA*) to investigate the impact of calcineurin activation on metabolic properties of skeletal muscle. Activation of calcineurin increased glucose incorporation into glycogen and lipid oxidation in skeletal muscle. Activated calcineurin suppressed skeletal muscle glucose oxidation and increased lactate release. The enhancement in lipid oxidation was supported by increased expression of genes for lipid metabolism and mitochondrial oxidative phosphorylation. In a reciprocal fashion, several genes of glycolysis were down-regulated, whereas pyruvate dehydrogenase kinase 4 was markedly induced. This expression pattern was associated with decreased glucose utilization and enhanced glycogen storage. The peroxisome proliferator-activated receptors (PPARs) and PPARgamma coactivator 1alpha (PGC1alpha) are transcription regulators for the expression of metabolic and mitochondrial genes. Consistent with changes in the gene-regulatory program, calcineurin promoted the expression of PPARalpha, PPARdelta, and PPARgamma coactivator 1alpha in skeletal muscle. These results provide evidence that calcineurin-mediated skeletal muscle reprogramming induces the expression of several transcription regulators that coordinate changes in the expression of genes for lipid and glucose metabolism, which in turn alters energy substrate utilization in skeletal muscle.-
dc.format.extent8 p.-
dc.format.mimetypeapplication/pdf-
dc.language.isoeng-
dc.publisherAmerican Society for Biochemistry and Molecular Biology-
dc.relation.isformatofReproducció del document publicat a: https://doi.org/10.1074/jbc.M609208200-
dc.relation.ispartofJournal of Biological Chemistry, 2007, vol. 282, num. 3, p. 1607-1614-
dc.relation.urihttps://doi.org/10.1074/jbc.M609208200-
dc.rights(c) American Society for Biochemistry and Molecular Biology, 2007-
dc.subject.classificationFarmacologia-
dc.subject.classificationExpressió gènica-
dc.subject.classificationMúsculs-
dc.subject.classificationMetabolisme-
dc.subject.otherPharmacology-
dc.subject.otherGene expression-
dc.subject.otherMuscles-
dc.subject.otherMetabolism-
dc.titleCalcineurin regulates skeletal muscle metabolism via coordinated changes in gene expression-
dc.typeinfo:eu-repo/semantics/article-
dc.typeinfo:eu-repo/semantics/publishedVersion-
dc.identifier.idgrec653059-
dc.date.updated2021-04-29T10:38:10Z-
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess-
dc.identifier.pmid17107952-
Appears in Collections:Articles publicats en revistes (Ciències Fisiològiques)

Files in This Item:
File Description SizeFormat 
653059.pdf418.85 kBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.