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http://hdl.handle.net/2445/176958
Title: | Intrinsically disordered proteins and biomolecular condensates as drug targets |
Author: | Biesaga, Mateusz Frigolé Vivas, Marta Salvatella i Giralt, Xavier |
Keywords: | Biomolècules Càncer Malalties neurodegeneratives Malalties infeccioses Biomolecules Cancer Neurodegenerative Diseases Communicable diseases |
Issue Date: | 31-Mar-2021 |
Publisher: | Elsevier Ltd. |
Abstract: | Intrinsically disordered domains represent attractive therapeutic targets because they play key roles in cancer, as well as in neurodegenerative and infectious diseases. They are, however, considered undruggable because they do not form stable binding pockets for small molecules and, therefore, have not been prioritized in drug discovery. Under physiological solution conditions many biomedically relevant intrinsically disordered proteins undergo phase separation processes leading to the formation of mesoscopic highly dynamic assemblies, generally known as biomolecular condensates that define environments that can be quite different from the solutions surrounding them. In what follows, we review key recent findings in this area and show how biomolecular condensation can offer opportunities for modulating the activities of intrinsically disordered targets.Copyright © 2021 Elsevier Ltd. All rights reserved. |
Note: | Versió postprint del document publicat a: https://doi.org/10.1016/j.cbpa.2021.02.009 |
It is part of: | Current Opinion In Chemical Biology, 2021, vol. 62, p. 90-100 |
URI: | http://hdl.handle.net/2445/176958 |
Related resource: | https://doi.org/10.1016/j.cbpa.2021.02.009 |
Appears in Collections: | Publicacions de projectes de recerca finançats per la UE Articles publicats en revistes (Institut de Recerca Biomèdica (IRB Barcelona)) |
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