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Title: Combined analysis of miR-200 family and its significance for breast cancer
Author: Fontana, Andrea
Barbano, Raffaela
Dama, Elisa
Pasculli, Barbara
Rendina, Michelina
Morritti, Maria Grazia
Melocchi, Valentina
Castelvetere, Marina
Valori, Vanna Maria
Ravaioli, Sara
Bravaccini, Sara
Ciuffreda, Luigi
Graziano, Paolo
Maiello, Evaristo
Copetti, Massimiliano
Fazio, Vito Michele
Esteller, Manel
Bianchi, Fabrizio
Parrella, Paola
Keywords: Marcadors bioquímics
Càncer de mama
Biochemical markers
Breast cancer
Issue Date: 3-Feb-2021
Publisher: Nature Publishing Group
Abstract: While the molecular functions of miR-200 family have been deeply investigated, a role for these miRNAs as breast cancer biomarkers remains largely unexplored. In the attempt to clarify this, we profiled the miR-200 family members expression in a large cohort of breast cancer cases with a long follow-up (H-CSS cohort) and in TCGA-BRCA cohort. Overall, miR-200 family was found upregulated in breast tumors with respect to normal breast tissues while downregulated in more aggressive breast cancer molecular subtypes (i.e. Luminal B, HER2 and triple negative), consistently with their function as repressors of the epithelial-to-mesenchymal transition (EMT). In particular miR-141-3p was found differentially expressed in breast cancer molecular subtypes in both H-CSS and TCGA-BRCA cohorts, and the combined analysis of all miR-200 family members demonstrated a slight predictive accuracy on H-CSS cancer specific survival at 12 years (survival c-statistic: 0.646; 95%CI 0.538-0.754).
Note: Reproducció del document publicat a:
It is part of: Scientific Reports, 2021, vol. 11, num. 1, p. 2980
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ISSN: 2045-2322
Appears in Collections:Articles publicats en revistes (Ciències Fisiològiques)

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