Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/177003
Title: | Combined analysis of miR-200 family and its significance for breast cancer |
Author: | Fontana, Andrea Barbano, Raffaela Dama, Elisa Pasculli, Barbara Rendina, Michelina Morritti, Maria Grazia Melocchi, Valentina Castelvetere, Marina Valori, Vanna Maria Ravaioli, Sara Bravaccini, Sara Ciuffreda, Luigi Graziano, Paolo Maiello, Evaristo Copetti, Massimiliano Fazio, Vito Michele Esteller, Manel Bianchi, Fabrizio Parrella, Paola |
Keywords: | Marcadors bioquímics Càncer de mama Biochemical markers Breast cancer |
Issue Date: | 3-Feb-2021 |
Publisher: | Nature Publishing Group |
Abstract: | While the molecular functions of miR-200 family have been deeply investigated, a role for these miRNAs as breast cancer biomarkers remains largely unexplored. In the attempt to clarify this, we profiled the miR-200 family members expression in a large cohort of breast cancer cases with a long follow-up (H-CSS cohort) and in TCGA-BRCA cohort. Overall, miR-200 family was found upregulated in breast tumors with respect to normal breast tissues while downregulated in more aggressive breast cancer molecular subtypes (i.e. Luminal B, HER2 and triple negative), consistently with their function as repressors of the epithelial-to-mesenchymal transition (EMT). In particular miR-141-3p was found differentially expressed in breast cancer molecular subtypes in both H-CSS and TCGA-BRCA cohorts, and the combined analysis of all miR-200 family members demonstrated a slight predictive accuracy on H-CSS cancer specific survival at 12 years (survival c-statistic: 0.646; 95%CI 0.538-0.754). |
Note: | Reproducció del document publicat a: https://doi.org/10.1038/s41598-021-82286-1 |
It is part of: | Scientific Reports, 2021, vol. 11, num. 1, p. 2980 |
URI: | http://hdl.handle.net/2445/177003 |
Related resource: | https://doi.org/10.1038/s41598-021-82286-1 |
ISSN: | 2045-2322 |
Appears in Collections: | Articles publicats en revistes (Ciències Fisiològiques) |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
707515.pdf | 3.96 MB | Adobe PDF | View/Open |
This item is licensed under a Creative Commons License