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http://hdl.handle.net/2445/177006
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DC Field | Value | Language |
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dc.contributor.author | Crispi Brillas, Fàtima | - |
dc.contributor.author | Crovetto, Francesca | - |
dc.contributor.author | Larroya, Marta | - |
dc.contributor.author | Camacho Sáez, Alba | - |
dc.contributor.author | Tortajada, Marta | - |
dc.contributor.author | Sibila Vidal, Oriol | - |
dc.contributor.author | Badia, Joan Ramon | - |
dc.contributor.author | López, Marta | - |
dc.contributor.author | Vellvé, Kilian | - |
dc.contributor.author | García, Ferràn | - |
dc.contributor.author | Trilla García, Antoni | - |
dc.contributor.author | Faner, Rosa | - |
dc.contributor.author | Blanco Vich, Isabel | - |
dc.contributor.author | Borràs, Roger | - |
dc.contributor.author | Agustí García-Navarro, Àlvar | - |
dc.contributor.author | Gratacós Solsona, Eduard | - |
dc.date.accessioned | 2021-05-04T20:49:04Z | - |
dc.date.available | 2021-05-04T20:49:04Z | - |
dc.date.issued | 2021-02-03 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | http://hdl.handle.net/2445/177006 | - |
dc.description.abstract | The identification of factors predisposing to severe COVID-19 in young adults remains partially characterized. Low birth weight (LBW) alters cardiovascular and lung development and predisposes to adult disease. We hypothesized that LBW is a risk factor for severe COVID-19 in non-elderly subjects. We analyzed a prospective cohort of 397 patients (18-70 years) with laboratory-confirmed SARS-CoV-2 infection attended in a tertiary hospital, where 15% required admission to Intensive Care Unit (ICU). Perinatal and current potentially predictive variables were obtained from all patients and LBW was defined as birth weight ≤ 2.500 g. Age (adjusted OR (aOR) 1.04 [1-1.07], P = 0.012), male sex (aOR 3.39 [1.72-6.67], P < 0.001), hypertension (aOR 3.37 [1.69-6.72], P = 0.001), and LBW (aOR 3.61 [1.55-8.43], P = 0.003) independently predicted admission to ICU. The area under the receiver-operating characteristics curve (AUC) of this model was 0.79 [95% CI, 0.74-0.85], with positive and negative predictive values of 29.1% and 97.6% respectively. Results were reproduced in an independent cohort, from a web-based survey in 1822 subjects who self-reported laboratory-positive SARS-CoV-2 infection, where 46 patients (2.5%) needed ICU admission (AUC 0.74 [95% CI 0.68-0.81]). LBW seems to be an independent risk factor for severe COVID-19 in non-elderly adults and might improve the performance of risk stratification algorithms. | - |
dc.format.extent | 8 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Nature Publishing Group | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1038/s41598-021-82389-9 | - |
dc.relation.ispartof | Scientific Reports, 2021, vol. 11, num. 1, p. 2909 | - |
dc.relation.uri | https://doi.org/10.1038/s41598-021-82389-9 | - |
dc.rights | cc-by (c) Crispi Brillas, Fàtima et al., 2021 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es | - |
dc.source | Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques) | - |
dc.subject.classification | COVID-19 | - |
dc.subject.classification | Pes corporal | - |
dc.subject.other | COVID-19 | - |
dc.subject.other | Body weight | - |
dc.title | Low birth weight as a potential risk factor for severe COVID-19 in adults | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 708697 | - |
dc.date.updated | 2021-05-04T20:49:04Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 33536488 | - |
Appears in Collections: | Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques) Articles publicats en revistes (BCNatal Fetal Medicine Research Center) |
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File | Description | Size | Format | |
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708697.pdf | 1.11 MB | Adobe PDF | View/Open |
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