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dc.contributor.authorCrispi Brillas, Fàtima-
dc.contributor.authorCrovetto, Francesca-
dc.contributor.authorLarroya, Marta-
dc.contributor.authorCamacho Sáez, Alba-
dc.contributor.authorTortajada, Marta-
dc.contributor.authorSibila, Oriol-
dc.contributor.authorBadia, Joan Ramon-
dc.contributor.authorLópez, Marta-
dc.contributor.authorVellvé, Kilian-
dc.contributor.authorGarcía, Ferràn-
dc.contributor.authorTrilla García, Antoni-
dc.contributor.authorFaner, Rosa-
dc.contributor.authorBlanco, Isabel-
dc.contributor.authorBorràs, Roger-
dc.contributor.authorAgustí García-Navarro, Àlvar-
dc.contributor.authorGratacós Solsona, Eduard-
dc.description.abstractThe identification of factors predisposing to severe COVID-19 in young adults remains partially characterized. Low birth weight (LBW) alters cardiovascular and lung development and predisposes to adult disease. We hypothesized that LBW is a risk factor for severe COVID-19 in non-elderly subjects. We analyzed a prospective cohort of 397 patients (18-70 years) with laboratory-confirmed SARS-CoV-2 infection attended in a tertiary hospital, where 15% required admission to Intensive Care Unit (ICU). Perinatal and current potentially predictive variables were obtained from all patients and LBW was defined as birth weight ≤ 2.500 g. Age (adjusted OR (aOR) 1.04 [1-1.07], P = 0.012), male sex (aOR 3.39 [1.72-6.67], P < 0.001), hypertension (aOR 3.37 [1.69-6.72], P = 0.001), and LBW (aOR 3.61 [1.55-8.43], P = 0.003) independently predicted admission to ICU. The area under the receiver-operating characteristics curve (AUC) of this model was 0.79 [95% CI, 0.74-0.85], with positive and negative predictive values of 29.1% and 97.6% respectively. Results were reproduced in an independent cohort, from a web-based survey in 1822 subjects who self-reported laboratory-positive SARS-CoV-2 infection, where 46 patients (2.5%) needed ICU admission (AUC 0.74 [95% CI 0.68-0.81]). LBW seems to be an independent risk factor for severe COVID-19 in non-elderly adults and might improve the performance of risk stratification algorithms.-
dc.format.extent8 p.-
dc.publisherNature Publishing Group-
dc.relation.isformatofReproducció del document publicat a:
dc.relation.ispartofScientific Reports, 2021, vol. 11, num. 1, p. 2909-
dc.rightscc-by (c) Crispi Brillas, Fàtima et al., 2021-
dc.subject.classificationPes corporal-
dc.subject.otherBody weight-
dc.titleLow birth weight as a potential risk factor for severe COVID-19 in adults-
Appears in Collections:Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques)

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