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Title: IL-7/IL-7R gene variants impact circulating IL-7/IL-7R homeostasis and ART-associated immune recovery status
Author: Ceausu, Andrea
Rodríguez Gallego, Esther
Perair, Joaquim
López Dupla, Miguel
Domingo, Pere
Viladés, Consuelo
Vidal Gonzalez, Judit
Peraire, María
Perpiñán, Carles
Pacheco, Yolanda María
Veloso, Sergi
Alba, Verónica
Vargas, Montserrat
Castellano, Alfonso J.
Ruíz Mateos, Ezequiel
Mallolas Masferrer, Josep
Vidal, Francesc
Rull, Anna
Keywords: Polimorfisme genètic
Genetic polymorphisms
Issue Date: 31-Oct-2019
Publisher: Nature Publishing Group
Abstract: A relationship between polymorphisms in genes encoding interleukin 7 (IL-7) and its cellular receptor (IL-7R) and antiretroviral therapy (ART)-associated immune recovery in HIV subjects has been previously reported. However, details of this relationship remain unclear, and the association of these polymorphisms with circulating IL-7/IL-7R levels is scarce. Here, we explored whether IL-7/IL-7R axis was associated with quantitative CD4+ T-cell recovery in HIV-infected subjects. IL-7/IL-7R polymorphisms were assessed by genotyping, and multiple inheritance models were used to estimate both, their association with low pre-ART CD4+ T-cell counts and incomplete immune recovery status after 48 weeks of suppressive ART. Integrated data from genetic variants association and soluble plasma IL-7/IL-7R quantification suggest that IL-7/IL-7R genotype expression could alter the homeostatic balance between soluble and membrane-bound receptors. The haplotype analyses indicates that allele combinations impacts pre-ART circulating CD4+ T-cell counts, immune recovery status and the absolute increment of CD4+ T-cell counts. The knowledge about how IL-7/IL-7R axis is related to quantitative CD4+ T-cell recovery and immune recovery status after initiating ART could be useful regarding T-cell reservoirs investigations in HIV subjects.
Note: Reproducció del document publicat a:
It is part of: Scientific Reports, 2019, vol. 9, num. 1, p. 15722
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ISSN: 2045-2322
Appears in Collections:Articles publicats en revistes (Medicina)

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