Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/177008
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Ceausu, Andrea | - |
dc.contributor.author | Rodríguez Gallego, Esther | - |
dc.contributor.author | Perair, Joaquim | - |
dc.contributor.author | López Dupla, Miguel | - |
dc.contributor.author | Domingo, Pere (Domingo Pedrol) | - |
dc.contributor.author | Viladés, Consuelo | - |
dc.contributor.author | Vidal Gonzalez, Judit | - |
dc.contributor.author | Peraire, María | - |
dc.contributor.author | Perpiñán, Carles | - |
dc.contributor.author | Pacheco, Yolanda María | - |
dc.contributor.author | Veloso, Sergi | - |
dc.contributor.author | Alba, Verónica | - |
dc.contributor.author | Vargas, Montserrat | - |
dc.contributor.author | Castellano, Alfonso J. | - |
dc.contributor.author | Ruíz Mateos, Ezequiel | - |
dc.contributor.author | Mallolas Masferrer, Josep | - |
dc.contributor.author | Vidal, Francesc | - |
dc.contributor.author | Rull, Anna | - |
dc.date.accessioned | 2021-05-04T21:02:06Z | - |
dc.date.available | 2021-05-04T21:02:06Z | - |
dc.date.issued | 2019-10-31 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | http://hdl.handle.net/2445/177008 | - |
dc.description.abstract | A relationship between polymorphisms in genes encoding interleukin 7 (IL-7) and its cellular receptor (IL-7R) and antiretroviral therapy (ART)-associated immune recovery in HIV subjects has been previously reported. However, details of this relationship remain unclear, and the association of these polymorphisms with circulating IL-7/IL-7R levels is scarce. Here, we explored whether IL-7/IL-7R axis was associated with quantitative CD4+ T-cell recovery in HIV-infected subjects. IL-7/IL-7R polymorphisms were assessed by genotyping, and multiple inheritance models were used to estimate both, their association with low pre-ART CD4+ T-cell counts and incomplete immune recovery status after 48 weeks of suppressive ART. Integrated data from genetic variants association and soluble plasma IL-7/IL-7R quantification suggest that IL-7/IL-7R genotype expression could alter the homeostatic balance between soluble and membrane-bound receptors. The haplotype analyses indicates that allele combinations impacts pre-ART circulating CD4+ T-cell counts, immune recovery status and the absolute increment of CD4+ T-cell counts. The knowledge about how IL-7/IL-7R axis is related to quantitative CD4+ T-cell recovery and immune recovery status after initiating ART could be useful regarding T-cell reservoirs investigations in HIV subjects. | - |
dc.format.extent | 10 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Nature Publishing Group | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1038/s41598-019-52025-8 | - |
dc.relation.ispartof | Scientific Reports, 2019, vol. 9, num. 1, p. 15722 | - |
dc.relation.uri | https://doi.org/10.1038/s41598-019-52025-8 | - |
dc.rights | cc-by (c) Ceausu, Andrea et al., 2019 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es | - |
dc.source | Articles publicats en revistes (Medicina) | - |
dc.subject.classification | Polimorfisme genètic | - |
dc.subject.classification | Interleucines | - |
dc.subject.other | Genetic polymorphisms | - |
dc.subject.other | Interleukins | - |
dc.title | IL-7/IL-7R gene variants impact circulating IL-7/IL-7R homeostasis and ART-associated immune recovery status | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 710309 | - |
dc.date.updated | 2021-05-04T21:02:07Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 31673011 | - |
Appears in Collections: | Articles publicats en revistes (Medicina) |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
710309.pdf | 1.74 MB | Adobe PDF | View/Open |
This item is licensed under a Creative Commons License