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Title: | Testing the efficacy of INtegral Cognitive REMediation (INCREM) in major depressive disorder: study protocol for a randomized clinical trial |
Author: | Vicent Gil, Muriel Raventós, Beatriz Marín Martínez, Eduardo D. González Simarro, Sara Martínez-Arán, Anabel, 1971- Bonnín, Caterina del Mar Trujols, Joan Pérez Blanco, Josefina de Diego Adeliño, Javier Puigdemont, Dolors Serra Blasco, María Cardoner, N. (Narcís) Portella Moll, María Jesús |
Keywords: | Depressió psíquica Rehabilitació cognitiva Mental depression Cognitive remediation |
Issue Date: | 6-May-2019 |
Publisher: | BioMed Central |
Abstract: | Background: Given the limitation of pharmacological treatments to treat cognitive symptoms in patients with Major Depressive Disorder (MDD), cognitive remediation programs has been proposed as a possible procognitive intervention but findings are not conclusive. This study investigates the efficacy of an INtegral Cognitive REMediation (INCREM) that includes a combination of a Functional Remediation (FR) strategy plus a Computerized Cognitive Training (CCT) in order to improve not only cognitive performance but also the psychosocial functioning and the quality of life. Methods: A single blind randomized controlled clinical trial in 81 patients with a diagnosis of MDD in clinical remission or in partial remission. Participants will be randomized to one of three conditions: INCREM (FR + CCT), Psychoeducation plus online games and Treatment As Usual (TAU). Intervention will consist in 12 group sessions, of approximately 110 min once a week. The primary outcome measure will be % of change in psychosocial functioning after treatment measured by the Functional Assessment Short Test (FAST); additionally, number of sick leaves and daily activities will also be recorded as pragmatic outcomes. Discussion: To our knowledge, this is the first randomized controlled clinical trial using a combination of two different approaches (FR + CCT) to treat the present cognitive deficits and to promote their improvements into a better psychosocial functioning. Trial registration: Clinical Trials NCT03624621 . Date registered 10th of August 2018 and last updated 24th August 2018. |
Note: | Reproducció del document publicat a: https://doi.org/10.1186/s12888-019-2117-4 |
It is part of: | BMC Psychiatry, 2019, vol. 19, num. 1, p. 135 |
URI: | http://hdl.handle.net/2445/177070 |
Related resource: | https://doi.org/10.1186/s12888-019-2117-4 |
ISSN: | 1471-244X |
Appears in Collections: | Articles publicats en revistes (Psicologia Clínica i Psicobiologia) |
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