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Title: DNA-interacting proteins in the spermiogenesis of the mollusc Murex brandaris
Author: Càceres, Carme
Giménez Bonafé, Pepita
Ribes Mora, Enric
Wouters-Tyroui, Danielle
Martinage, Arlette
Kouachi, Mostafa
Sautière, Pierre
Muller, Sylviane
Palau, Jaume
Subirana, Juan A.
Cornudella, Luis
Chiva i Royo, Manuel
Keywords: ADN
Issue Date: 8-Jan-1999
Publisher: American Society for Biochemistry and Molecular Biology
Abstract: Sperm chromatin of Murex brandaris (a neogastropod mollusc) undergoes a series of structural transitions during spermiogenesis. The DNA-interacting proteins responsible for these changes as well as the mature protamines present in the ripe sperm nucleus have been characterized. The results reveal that spermiogenic nuclear proteins are protamine precursors that are subjected to a substantial number of small N-terminal deletions that gradually modify their overall charge. The composition of mature protamines is remarkably simple in turn, promoting an efficient and extremely tight packaging of DNA. The pattern of spermiogenic chromatin condensation in M. brandaris clearly departs from that corresponding to vertebrate chromatin.
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It is part of: Journal of Biological Chemistry, 1999, vol. 274, num. 2, p. 649-656
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ISSN: 0021-9258
Appears in Collections:Articles publicats en revistes (Biologia Cel·lular, Fisiologia i Immunologia)
Articles publicats en revistes (Ciències Fisiològiques)

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