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Title: Risk Factors of Daptomycin-Induced Eosinophilic Pneumonia in a Population with Osteoarticular Infection
Author: Soldevila, Laura
Villanueva, Bernat
Ulldemolins, Marta
Benavent Palomares, Eva
Padulles Zamora, Ariadna
Ribera Puig, Alba
Borras, Irene
Ariza Cardenal, Javier
Murillo Rubio, Óscar
Keywords: Pneumònia
Malalties bacterianes grampositives
Gram-positive bacterial infections
Issue Date: 16-Apr-2021
Publisher: MDPI
Abstract: Background: Daptomycin-induced eosinophilic pneumonia (DEP) is a rare but severe adverse effect and the risk factors are unknown. The aim of this study was to determine risk factors for DEP. Methods: A retrospective cohort study was performed at the Bone and Joint Infection Unit of the Hospital Universitari Bellvitge (January 2014-December 2018). To identify risk factors for DEP, cases were divided into two groups: those who developed DEP and those without DEP. Results: Among the whole cohort (n = 229) we identified 11 DEP cases (4.8%) and this percentage almost doubled in the subgroup of patients ≥70 years (8.1%). The risk factors for DEP were age ≥70 years (HR 10.19, 95%CI 1.28-80.93), therapy >14 days (7.71, 1.98-30.09) and total cumulative dose of daptomycin ≥10 g (5.30, 1.14-24.66). Conclusions: Clinicians should monitor cumulative daptomycin dosage to minimize DEP risk, and be cautious particularly in older patients when the total dose of daptomycin exceeds 10 g.
Note: Reproducció del document publicat a:
It is part of: Antibiotics, 2021, vol. 10, num. 4
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Appears in Collections:Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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