Please use this identifier to cite or link to this item:
Title: Evaluation of renographic and metabolic parameters in human Kidney transplantation
Author: González Sistal, Ángel
Vigués i Julià, Francesc
Puchal Añé, Rafael
Franco Miranda, Eladio
Bartrons Bach, Ramon
Ambrosio Viale, Santiago
Keywords: Trasplantament renal
Diagnòstic per la imatge
Kidney transplantation
Diagnostic imaging
Issue Date: 1-Mar-1997
Publisher: The Society of Nuclear Medicine and Molecular Imaging
Abstract: Background: the aim of this work is to demonstrate that the value of the mean transit time (MTT) obtained from the 99mTc-MAG3 renogram deconvolution is related to the levels of adenine nucleotides determined in cortical biopsies from transplanted kidneys. Methods: the functional state was estimated by means of the MTT and the initial height (H0) of the renal retention function obtained from the 99mTc-MAG3 renogram deconvolution and by the measure of adenine nucleotides obtained from biopsies. We studied 30 kidney graft recipients, 25 normal functioning grafts (NFG) and 5 with acute tubular necrosis (ATN). Results: the MTT is significantly longer for ATN (p < 0.001). The initial uptake values (H0) are significantly lower for ATN (p < 0.001). The sum of adenine nucleotides (SAN) is significantly greater for NFG than for ATN (p < 0.001). The values of the MTT seem to reflect the energy state of the cells in transplanted kidney. Conclusion: the analysis of MTT may be indicative of the functional metabolic recovery and thus it may be predictive of the renal graft function at least in the same extent than the biochemical analysis of a cortical renal biopsy immediately after blood reperfusion of the tissue.
Note: Reproducció del document publicat a:
It is part of: Journal of Nuclear Medicine, 1997, vol. 41, num. 1, p. 42-45
ISSN: 0161-5505
Appears in Collections:Articles publicats en revistes (Ciències Clíniques)
Articles publicats en revistes (Ciències Fisiològiques)

Files in This Item:
File Description SizeFormat 
535747.pdf3.48 MBAdobe PDFView/Open

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.