Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/177367
Title: | Five-year results of accelerated partial breast irradiation: a single institution retrospective review of 289 cases |
Author: | Laplana, Maria Cozzi, Salvatore Najjari, Dina Martín, Marta Irene Rodríguez, Gerard Slocker, Andrea Sancho, Ismael Pla Farnós, María Jesús García, Marc Gracia, Ruth Pera Fàbregas, Joan Guedea Edo, Ferran Gutiérrez Miguélez, Cristina |
Keywords: | Càncer de mama Radiació Braquiteràpia Breast cancer Radiation Radioisotope brachytherapy |
Issue Date: | 30-Mar-2021 |
Publisher: | Elsevier |
Abstract: | Purpose: the purpose of the study was to describe our institutional experience with accelerated partial breast irradiation (APBI) using multicatheter brachytherapy with high-dose-rate. We report 5-year survival outcomes, cosmesis, and treatment-related toxicity. Methods and materials: this included a retrospective review of patients who underwent breast-conserving surgery followed by APBI at our institution from 2004 to 2017. Results: a total of 289 patients were evaluated. Median followup was 72 months. Median age was 70 years. APBI was the only primary treatment in 86.2% of cases with early-stage breast cancer and a second conservative treatment in 13.8%. The implant was performed postoperatively in 213 patients (73.7%) and intraoperatively in 76 (26.3%). The most common radiation schemes were 10 fractions of 3.4 Gy and eight fractions of 4 Gy. Elderly or frail patients (10%) received a single 16 Gy dose. Of the 289 patients, 215 met Groupe Europ een de Curieth erapie-European Society for Radiotherapy and Oncology criteria for APBI; in this group, late side effects included Grade 2 (G2) fibrosis (14.8%), skin discoloration at the catheter points (8.8%), and telangiectasia (0.5%). The cosmetic result was considered excellent or good in 88.3% of cases. Five-year local control, disease-free, cancer-specific, and overall survival rates were 98.9%, 96.7%, 99.1%, and 95.6%, respectively. Conclusions: local control and survival outcomes at 5 years of followup in this group of well-selected patients were excellent, with low rates of treatment-related toxicity. These findings confirm the safety and effectiveness of APBI, even in elderly and frail patients. These results provide further support for the clinical use of APBI in suitable patients. 2021 Published by Elsevier Inc. on behalf of American Brachytherapy Society. |
Note: | Versió postprint del document publicat a: https://doi.org/10.1016/j.brachy.2021.02.003 |
It is part of: | Brachytherapy, 2021 |
URI: | http://hdl.handle.net/2445/177367 |
Related resource: | https://doi.org/10.1016/j.brachy.2021.02.003 |
ISSN: | 1538-4721 |
Appears in Collections: | Articles publicats en revistes (Ciències Clíniques) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
712067.pdf | 709.16 kB | Adobe PDF | View/Open |
This item is licensed under a Creative Commons License