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http://hdl.handle.net/2445/177408
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DC Field | Value | Language |
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dc.contributor.author | van Werkhoven, Cornelis H. | - |
dc.contributor.author | Ducher, Annie | - |
dc.contributor.author | Berkell, Matilda | - |
dc.contributor.author | Mysara, Mohamed | - |
dc.contributor.author | Lammens, Christine | - |
dc.contributor.author | Torre Cisneros, Julian | - |
dc.contributor.author | Rodríguez Baño, Jesús | - |
dc.contributor.author | Herghera, Delia | - |
dc.contributor.author | Cornely, Oliver A. | - |
dc.contributor.author | Biehl, Lena M. | - |
dc.contributor.author | Bernard, Louis | - |
dc.contributor.author | Domínguez Luzón, Ma. Ángeles (María Ángeles) | - |
dc.contributor.author | Maraki, Sofia | - |
dc.contributor.author | Barraud, Olivier | - |
dc.contributor.author | Nica, Maria | - |
dc.contributor.author | Jazmati, Nathalie | - |
dc.contributor.author | Sablier, Frederique | - |
dc.contributor.author | Gunzburg, Jean de | - |
dc.contributor.author | Mentré, France | - |
dc.contributor.author | Malhotra-Kumar, Surbhi | - |
dc.contributor.author | Bonten, Marc J. M. | - |
dc.contributor.author | Vehreschild, Maria J. G. T. | - |
dc.contributor.author | Pujol Rojo, Miquel | - |
dc.contributor.author | ANTICIPATE Study Group | - |
dc.date.accessioned | 2021-05-19T12:23:19Z | - |
dc.date.available | 2021-05-19T12:23:19Z | - |
dc.date.issued | 2021 | - |
dc.identifier.issn | 2041-1723 | - |
dc.identifier.uri | http://hdl.handle.net/2445/177408 | - |
dc.description.abstract | Trial enrichment using gut microbiota derived biomarkers by high-risk individuals can improve the feasibility of randomized controlled trials for prevention of Clostridioides difficile infection (CDI). Here, we report in a prospective observational cohort study the incidence of CDI and assess potential clinical characteristics and biomarkers to predict CDI in 1,007 patients ≥ 50 years receiving newly initiated antibiotic treatment with penicillins plus a beta- lactamase inhibitor, 3rd/4th generation cephalosporins, carbapenems, fluoroquinolones or clindamycin from 34 European hospitals. The estimated 90-day cumulative incidences of a first CDI episode is 1.9% (95% CI 1.1-3.0). Carbapenem treatment (Hazard Ratio (95% CI): 5.3 (1.7-16.6)), toxigenic C. difficile rectal carriage (10.3 (3.2-33.1)), high intestinal abundance of Enterococcus spp. relative to Ruminococcus spp. (5.4 (2.1-18.7)), and low Shannon alpha diversity index as determined by 16 S rRNA gene profiling (9.7 (3.2-29.7)), but not nor- malized urinary 3-indoxyl sulfate levels, predicts an increased CDI risk. | - |
dc.format.extent | 10 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Nature Publishing Group | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1038/s41467-021-22269-y | - |
dc.relation.ispartof | Nature Communications, 2021, vol. 12 | - |
dc.relation.uri | https://doi.org/10.1038/s41467-021-22269-y | - |
dc.rights | cc-by (c) van Werkhoven et al., 2021 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.source | Articles publicats en revistes (Patologia i Terapèutica Experimental) | - |
dc.subject.classification | Malalties bacterianes | - |
dc.subject.classification | Antibiòtics | - |
dc.subject.classification | Microbiota | - |
dc.subject.other | Bacterial diseases | - |
dc.subject.other | Antibiotics | - |
dc.subject.other | Microbiota | - |
dc.title | Incidence and predictive biomarkers of Clostridioides difficile infection in hospitalized patients receiving broad-spectrum antibiotics | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 711934 | - |
dc.date.updated | 2021-05-19T12:23:19Z | - |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/FP7/115523/EU//COMBACTE-NET | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 33854064 | - |
Appears in Collections: | Articles publicats en revistes (Patologia i Terapèutica Experimental) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) Publicacions de projectes de recerca finançats per la UE |
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711934.pdf | 734.65 kB | Adobe PDF | View/Open |
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