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Title: Optical Control of GABAA Receptors with a Fulgimide-Based Potentiator
Author: Rustler, Karin
Maleeva, Galyna
Gomila Juaneda, Alexandre
Gorostiza Langa, Pablo Ignacio
Bregestovski, Piotr
König, Burkhard
Keywords: Fototeràpia
Neural transmission
Issue Date: 6-Oct-2020
Publisher: Wiley-VCH GmbH
Abstract: Optogenetic and photopharmacological tools to manipulate neuronal inhibition have limited efficacy and reversibility. We report the design, synthesis, and biological evaluation of Fulgazepam, a fulgimide derivative of benzodiazepine that behaves as a pure potentiator of ionotropic γ-aminobutyric acid receptors (GABA A Rs) and displays full and reversible photoswitching in vitro and in vivo. The compound enables high-resolution studies of GABAergic neurotransmission, and phototherapies based on localized, acute, and reversible neuroinhibition.
Note: Reproducció del document publicat a:
It is part of: Chemistry - A European Journal, 2020, vol. 26, num. 56, p. 12722-12727
Appears in Collections:Articles publicats en revistes (Institut de Bioenginyeria de Catalunya (IBEC))

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