Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/177690
Title: | Molecular Epidemiology of Klebsiella pneumoniae Strains Causing Bloodstream Infections in Adults |
Author: | Cubero, Meritxell Grau, Immaculada Tubau, Fe Pallarés Giner, Roman Domínguez Luzón, Ma. Ángeles (María Ángeles) Liñares Louzao, Josefina Ardanuy Tisaire, María Carmen |
Keywords: | Microbiologia Klebsiella pneumoniae Genètica Microbiology Klebsiella pneumoniae Genetics |
Issue Date: | 1-Sep-2018 |
Publisher: | Mary Ann Liebert |
Abstract: | Molecular epidemiology of Klebsiella pneumoniae bacteremic strains allows for a better understanding of preventive and therapeutic strategies. Clinical and microbiological characteristics of 348 K. pneumoniae bacteremia cases (2007-2009) were retrospectively characterized by multilocus sequence typing and extended-spectrum beta-lactamases (ESBL) production. Overall, 223 (64.08%) cases were nosocomial (NA), 58 (16.67%) healthcare associated, and 67 (19.25%) community acquired. The main infection origins were urinary tract (16.6%, 50.0%, and 43.3%), biliary tract (10.8%, 24.2%, and 31.3%), and catheter-related infection (39.9%, 5.2%, and 0%). The 30-day mortality rate was around 20%. The rates of resistance were around 45% the highest being among NA cases, and ESBL production was detected in 7.2% of cases. A total of 161 different sequence types were grouped into 13 clonal sets by e-burst analysis. No relationship could be established between clonal sets and the origin of infection or the healthcare-related settings. The high genetic variability among the isolates suggests their intrapatient endogenous origin. |
Note: | Versió postprint del document publicat a: https://doi.org/10.1089/mdr.2017.0107 |
It is part of: | Microbial Drug Resistance, 2018, vol. 24, num. 7, p. 949-957 |
URI: | http://hdl.handle.net/2445/177690 |
Related resource: | https://doi.org/10.1089/mdr.2017.0107 |
ISSN: | 1076-6294 |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) Articles publicats en revistes (Ciències Clíniques) Articles publicats en revistes (Patologia i Terapèutica Experimental) |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
677829.pdf | 411.09 kB | Adobe PDF | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.