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Title: | Impact of HLA Mismatching on Early Subclinical Inflammation in Low-Immunological-Risk Kidney Transplant Recipients |
Author: | Hernández, Domingo Vázquez, Teresa Alonso Titos, Juana León, Myriam Caballero, Abelardo Cobo, María Angeles Sola, Eugenia López, Verónica Ruiz Esteban, Pedro Cruzado, Josep Ma. Sellarés, Joana Moreso, Francesc Manonelles, Anna Torio, Alberto Cabello, Mercedes Delgado Burgos, Juan Casas, Cristina Gutiérrez, Elena Jironda, Cristina Kanter, Julia Serón, Daniel Torres, Armando |
Keywords: | Trasplantament renal Inflamació Kidney transplantation Inflammation |
Issue Date: | 29-Apr-2021 |
Publisher: | MDPI |
Abstract: | The impact of human leukocyte antigen (HLA)-mismatching on the early appearance of subclinical inflammation (SCI) in low-immunological-risk kidney transplant (KT) recipients is undetermined. We aimed to assess whether HLA-mismatching (A-B-C-DR-DQ) is a risk factor for early SCI. As part of a clinical trial (Clinicaltrials.gov, number NCT02284464), a total of 105 low-immunological-risk KT patients underwent a protocol biopsy on the third month post-KT. As a result, 54 presented SCI, showing a greater number of total HLA-mismatches (p = 0.008) and worse allograft function compared with the no inflammation group (48.5 ± 13.6 vs. 60 ± 23.4 mL/min; p = 0.003). Multiple logistic regression showed that the only risk factor associated with SCI was the total HLA-mismatch score (OR 1.32, 95%CI 1.06-1.64, p = 0.013) or class II HLA mismatching (OR 1.51; 95%CI 1.04-2.19, p = 0.032) after adjusting for confounder variables (recipient age, delayed graft function, transfusion prior KT, and tacrolimus levels). The ROC curve illustrated that the HLA mismatching of six antigens was the optimal value in terms of sensitivity and specificity for predicting the SCI. Finally, a significantly higher proportion of SCI was seen in patients with >6 vs. ≤6 HLA-mismatches (62.3 vs. 37.7%; p = 0.008). HLA compatibility is an independent risk factor associated with early SCI. Thus, transplant physicians should perhaps be more aware of HLA mismatching to reduce these early harmful lesions. |
Note: | Reproducció del document publicat a: https://doi.org/10.3390/jcm10091934 |
It is part of: | Journal of Clinical Medicine, 2021, vol. 10, num. 9 |
URI: | http://hdl.handle.net/2445/177758 |
Related resource: | https://doi.org/10.3390/jcm10091934 |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) Articles publicats en revistes (Ciències Clíniques) |
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