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http://hdl.handle.net/2445/177825
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DC Field | Value | Language |
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dc.contributor.author | Seppälä, Toni T. | - |
dc.contributor.author | Dominguez Valentin, Mev | - |
dc.contributor.author | Crosbie, Emma J. | - |
dc.contributor.author | Engel, Christoph | - |
dc.contributor.author | Aretz, Stefan | - |
dc.contributor.author | Macrae, Finlay | - |
dc.contributor.author | Winship, Ingrid | - |
dc.contributor.author | Capellá, G. (Gabriel) | - |
dc.contributor.author | Thomas, Huw | - |
dc.contributor.author | Hovig, Eivind | - |
dc.contributor.author | Nielsen, Maartje | - |
dc.contributor.author | Sijmons, Rolf H. | - |
dc.contributor.author | Bertario, Lucio | - |
dc.contributor.author | Bonanni, Bernardo | - |
dc.contributor.author | Tibiletti, Maria G. | - |
dc.contributor.author | Cavestro, Giulia Martina | - |
dc.contributor.author | Mints, Miriam | - |
dc.contributor.author | Gluck, Nathan | - |
dc.contributor.author | Katz, Lior | - |
dc.contributor.author | Heinimann, Karl | - |
dc.contributor.author | Vaccaro, Carlos A. | - |
dc.contributor.author | Green, Kate | - |
dc.contributor.author | Lalloo, Fiona | - |
dc.contributor.author | Hill, James | - |
dc.contributor.author | Schmiegel, Wolff | - |
dc.contributor.author | Vangala, Deepak | - |
dc.contributor.author | Perne, Claudia | - |
dc.contributor.author | Strauß, Hans Georg | - |
dc.contributor.author | Tecklenburg, Johanna | - |
dc.contributor.author | Holinski Feder, Elke | - |
dc.contributor.author | Steinke Lange, Verena | - |
dc.contributor.author | Mecklin, Jukka-Pekka | - |
dc.contributor.author | Plazzer, John Paul | - |
dc.contributor.author | Pineda Riu, Marta | - |
dc.contributor.author | Navarro García, Matilde | - |
dc.contributor.author | Vida, Joan B. | - |
dc.contributor.author | Kariv, Revital | - |
dc.contributor.author | Rosner, Guy | - |
dc.contributor.author | Piñero, Tamara A. | - |
dc.contributor.author | Pavicic, Walter Hernán | - |
dc.contributor.author | Kalfayan, Pablo | - |
dc.contributor.author | Ten Broeke, Sanne W. | - |
dc.contributor.author | Jenkins, Mark A. | - |
dc.contributor.author | Sunde, Lone | - |
dc.contributor.author | Bernstein, Inge | - |
dc.contributor.author | Burn, John | - |
dc.contributor.author | Greenblatt, Marc | - |
dc.contributor.author | De Vos Tot Nederveen Cappel, Wouter H. | - |
dc.contributor.author | Della Valle, Adriana | - |
dc.contributor.author | Lopez Kostner, Francisco | - |
dc.contributor.author | Alvarez Valenzuela, Karin | - |
dc.contributor.author | Büttner, Reinhard | - |
dc.contributor.author | Görgens, Heike | - |
dc.contributor.author | Morak, Monika | - |
dc.contributor.author | Holzapfel, Stefanie | - |
dc.contributor.author | Hüneburg, Robert | - |
dc.contributor.author | Von Knebel Doeberitz, Magnus | - |
dc.contributor.author | Loeffler, Markus | - |
dc.contributor.author | Redler, Silke | - |
dc.contributor.author | Weitz, Jürgen | - |
dc.contributor.author | Pylvänäinen, Kirsi | - |
dc.contributor.author | Renkonen Sinisalo, Laura | - |
dc.contributor.author | Lepistö, Anna | - |
dc.contributor.author | Hopper, John L. | - |
dc.contributor.author | Win, Aung K. | - |
dc.contributor.author | Lindor, Noralane M. | - |
dc.contributor.author | Gallinger, Steven | - |
dc.contributor.author | Le Marchand, Loïc | - |
dc.contributor.author | Newcomb, Polly A. | - |
dc.contributor.author | Figueiredo, Jane C. | - |
dc.contributor.author | Thibodeau, Stephen N. | - |
dc.contributor.author | Therkildsen, Christina | - |
dc.contributor.author | Wadt, Karin A.W. | - |
dc.contributor.author | Mourits, Marian J.E. | - |
dc.contributor.author | Ketabi, Zohreh | - |
dc.contributor.author | Denton, Oliver G. | - |
dc.contributor.author | Rødland, Einar A. | - |
dc.contributor.author | Vasen, Hans | - |
dc.contributor.author | Neffa, Florencia | - |
dc.contributor.author | Esperon, Patricia | - |
dc.contributor.author | Tjandra, Douglas | - |
dc.contributor.author | Möslein, Gabriela | - |
dc.contributor.author | Sampson, Julian R. | - |
dc.contributor.author | Rokkones, Erik | - |
dc.contributor.author | Evans, D. Gareth | - |
dc.contributor.author | Møller, Pål | - |
dc.date.accessioned | 2021-05-31T12:39:35Z | - |
dc.date.available | 2021-05-31T12:39:35Z | - |
dc.date.issued | 2021-03-17 | - |
dc.identifier.issn | 0959-8049 | - |
dc.identifier.uri | http://hdl.handle.net/2445/177825 | - |
dc.description.abstract | Purpose: This study aimed to report the uptake of hysterectomy and/or bilateral salpingo-oophorectomy (BSO) to prevent gynaecological cancers (risk-reducing surgery [RRS]) in carriers of pathogenic MMR (path_MMR) variants. Methods: The Prospective Lynch Syndrome Database (PLSD) was used to investigate RRS by a cross-sectional study in 2292 female path_MMR carriers aged 30e69 years. Results: Overall, 144, 79, and 517 carriers underwent risk-reducing hysterectomy, BSO, or both combined, respectively. Two-thirds of procedures before 50 years of age were combined hysterectomy and BSO, and 81% of all procedures included BSO. Risk-reducing hysterectomy was performed before age 50 years in 28%, 25%, 15%, and 9%, and BSO in 26%, 25%, 14% and 13% of path_MLH1, path_MSH2, path_MSH6, and path_PMS2 carriers, respectively. Before 50 years of age, 107 of 188 (57%) BSO and 126 of 204 (62%) hysterectomies were performed in women without any prior cancer, and only 5% (20/392) were performed simultaneously with colorectal cancer (CRC) surgery. Conclusion: Uptake of RRS before 50 years of age was low, and RRS was rarely undertaken in association with surgical treatment of CRC. Uptake of RRS aligned poorly with gene- and age-associated risk estimates for endometrial or ovarian cancer that were published recently from PLSD and did not correspond well with current clinical guidelines. The reasons should be clarified. Decision-making on opting for or against RRS and its timing should be better aligned with predicted risk and mortality for endometrial and ovarian cancer in Lynch syn- drome to improve outcomes. | - |
dc.format.extent | 10 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Elsevier B.V. | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1016/j.ejca.2021.02.022 | - |
dc.relation.ispartof | European Journal of Cancer, 2021, vol. 148, p. 124-133 | - |
dc.relation.uri | https://doi.org/10.1016/j.ejca.2021.02.022 | - |
dc.rights | cc-by-nc-nd (c) Seppälä, Toni T. et al., 2021 | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | - |
dc.source | Articles publicats en revistes (Ciències Clíniques) | - |
dc.subject.classification | Càncer d'ovari | - |
dc.subject.classification | Càncer d'endometri | - |
dc.subject.classification | Mortalitat | - |
dc.subject.other | Ovarian cancer | - |
dc.subject.other | Endometrial cancer | - |
dc.subject.other | Mortality | - |
dc.title | Uptake of hysterectomy and bilateral salpingo-oophorectomy in carriers of pathogenic mismatch repair variants: a Prospective Lynch Syndrome Database report | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 711642 | - |
dc.date.updated | 2021-05-31T12:39:35Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 33743481 | - |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) Articles publicats en revistes (Ciències Clíniques) |
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