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http://hdl.handle.net/2445/177844
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DC Field | Value | Language |
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dc.contributor.author | García García de Paredes, Ana | - |
dc.contributor.author | Manicardi, Nicolo | - |
dc.contributor.author | Tellez, Luis | - |
dc.contributor.author | Ibañez, Luis | - |
dc.contributor.author | Royo, Félix | - |
dc.contributor.author | Bermejo, Javier | - |
dc.contributor.author | Blanco, Carolina | - |
dc.contributor.author | Fondevila Campo, Constantino | - |
dc.contributor.author | Fernández Lanza, Val | - |
dc.contributor.author | García Bermejo, Laura | - |
dc.contributor.author | Falcón Pérez, Juan Manuel | - |
dc.contributor.author | Bañares, Rafael | - |
dc.contributor.author | Gracia Sancho, Jordi | - |
dc.contributor.author | Albillos, Agustín | - |
dc.date.accessioned | 2021-06-01T09:42:33Z | - |
dc.date.available | 2021-06-01T09:42:33Z | - |
dc.date.issued | 2020-12-02 | - |
dc.identifier.issn | 2471-254X | - |
dc.identifier.uri | http://hdl.handle.net/2445/177844 | - |
dc.description.abstract | Noninvasive staging of decompensated cirrhosis is an unmet clinical need. The aims of this study were to characterize and validate a novel microRNA (miRNA) signature to stage decompensated cirrhosis and predict the portal pressure and systolic cardiac response to nonselective beta-blockers (NSBBs). Serum samples from patients with decompensated cirrhosis (n = 36) and healthy controls (n = 36) were tested for a novel signature of five miRNAs (miR-452-5p, miR-429, miR-885-5p, miR-181b-5p, and miR-122-5p) identified in the secretome of primary human hepatocytes and for three miRNAs (miR-192-5p, miR-34a-5p, and miR-29a-5p) previously discovered as biomarkers of chronic liver disease. All patients had ascites, which was refractory in 18 (50%), and were placed on NSBBs for variceal bleeding prophylaxis. In all patients, serum miRNAs, hepatic venous pressure gradient, and an echocardiogram study were performed before and 1 month after NSBBs. Patients with cirrhosis had lower serum levels of miR-429, miR-885-5p, miR-181b-5p, miR-122-5p, miR-192-5p, and miR-29a-5p (P < 0.05). Baseline serum miR-452-5p and miR-429 levels were lower in NSBB responders (P = 0.006). miR-181b-5p levels were greater in refractory ascites than in diuretic-sensitive ascites (P = 0.008) and correlated with serum creatinine. miR-452-5p and miR-885-5p were inversely correlated with baseline systemic vascular resistance (ρ = −0.46, P = 0.007; and ρ = −0.41, P = 0.01, respectively) and with diminished systolic contractility (ρ = −0.55, P = 0.02; and ρ = −0.55, P = 0.02, respectively) in patients with refractory ascites after NSBBs. Conclusion: Analysis of a miRNA signature in serum discriminates between patients with decompensated cirrhosis who show more severe systemic circulatory dysfunction and compromised systolic function after beta-blockade and those more likely to benefit from NSBBs. | - |
dc.format.extent | 14 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | John Wiley & Sons | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1002/hep4.1642 | - |
dc.relation.ispartof | Hepatology Communications, 2020, vol. 5, num. 2, p. 309-322 | - |
dc.relation.uri | https://doi.org/10.1002/hep4.1642 | - |
dc.rights | cc-by (c) García García de Paredes, Ana et al., 2020 | - |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | - |
dc.source | Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques) | - |
dc.subject.classification | Cirrosi hepàtica | - |
dc.subject.classification | Micro RNAs | - |
dc.subject.classification | Marcadors bioquímics | - |
dc.subject.other | Hepatic cirrhosis | - |
dc.subject.other | MicroRNAs | - |
dc.subject.other | Biochemical markers | - |
dc.title | Molecular Profiling of Decompensated Cirrhosis by a Novel MicroRNA Signature | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 705487 | - |
dc.date.updated | 2021-06-01T09:42:33Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 33553977 | - |
Appears in Collections: | Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques) Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) |
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705487.pdf | 969.85 kB | Adobe PDF | View/Open |
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