Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/177973
Title: Risk categories in COVID-19 based on degrees of inflammation: data on more than 17,000 patients from the Spanish SEMI-COVID-19 registry
Author: Rubio-Rivas, Manuel
Corbella, Xavier
Formiga Pérez, Francesc
Menéndez Fernández, Estela
Martín Escalante, María Dolores
Baños Fernández, Isolina
Arnalich Fernández, Francisco
Corral-Beamonte, Esther del
Lalueza, Antonio
Parra Virto, Alejandro
Roy Vallejo, Emilia
Loureiro Amigo, Jose
Álvarez Suárez, Ana María
Abadía-Otero, Jesica
Navarro de la Chica, María
Estévez González, Raquel
Hernández Milián, Almudena
Areses Manrique, María
Blázquez Encinar, Julio César
González Noya, Amara
González Ferrer, Ruth
Pérez Aguilera, María
Gil Sánchez, Ricardo
Millán Núñez-Cortés, Jesús
Casas Rojo, José
SEMI-COVID-19 Network
Keywords: COVID-19
Citoquines
Mortalitat
COVID-19
Cytokines
Mortality
Issue Date: 1-May-2021
Publisher: MDPI
Abstract: Background: the inflammation or cytokine storm that accompanies COVID-19 marks the prognosis. This study aimed to identify three risk categories based on inflammatory parameters on admission. Methods: retrospective cohort study of patients diagnosed with COVID-19, collected and followed-up from 1 March to 31 July 2020, from the nationwide Spanish SEMI-COVID-19 Registry. The three categories of low, intermediate, and high risk were determined by taking into consideration the terciles of the total lymphocyte count and the values of C-reactive protein, lactate dehydrogenase, ferritin, and D-dimer taken at the time of admission. Results: a total of 17,122 patients were included in the study. The high-risk group was older (57.9 vs. 64.2 vs. 70.4 years; p < 0.001) and predominantly male (37.5% vs. 46.9% vs. 60.1%; p < 0.001). They had a higher degree of dependence in daily tasks prior to admission (moderate-severe dependency in 10.8% vs. 14.1% vs. 17%; p < 0.001), arterial hypertension (36.9% vs. 45.2% vs. 52.8%; p < 0.001), dyslipidemia (28.4% vs. 37% vs. 40.6%; p < 0.001), diabetes mellitus (11.9% vs. 17.1% vs. 20.5%; p < 0.001), ischemic heart disease (3.7% vs. 6.5% vs. 8.4%; p < 0.001), heart failure (3.4% vs. 5.2% vs. 7.6%; p < 0.001), liver disease (1.1% vs. 3% vs. 3.9%; p = 0.002), chronic renal failure (2.3% vs. 3.6% vs. 6.7%; p < 0.001), cancer (6.5% vs. 7.2% vs. 11.1%; p < 0.001), and chronic obstructive pulmonary disease (5.7% vs. 5.4% vs. 7.1%; p < 0.001). They presented more frequently with fever, dyspnea, and vomiting. These patients more frequently required high flow nasal cannula (3.1% vs. 4.4% vs. 9.7%; p < 0.001), non-invasive mechanical ventilation (0.9% vs. 3% vs. 6.3%; p < 0.001), invasive mechanical ventilation (0.6% vs. 2.7% vs. 8.7%; p < 0.001), and ICU admission (0.9% vs. 3.6% vs. 10.6%; p < 0.001), and had a higher percentage of in-hospital mortality (2.3% vs. 6.2% vs. 23.9%; p < 0.001). The three risk categories proved to be an independent risk factor in multivariate analyses. Conclusion: the present study identifies three risk categories for the requirement of high flow nasal cannula, mechanical ventilation, ICU admission, and in-hospital mortality based on lymphopenia and inflammatory parameters.
Note: Reproducció del document publicat a: https://doi.org/10.3390/jcm10102214
It is part of: Journal of Clinical Medicine, 2021, vol. 10, num. 10, p. 2214
URI: http://hdl.handle.net/2445/177973
Related resource: https://doi.org/10.3390/jcm10102214
ISSN: 2077-0383
Appears in Collections:Articles publicats en revistes (Ciències Clíniques)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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