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Title: Interaction between cardiovascular risk factors and body mass index and 10-year incidence of cardiovascular disease, cancer death, and overall mortality
Author: Barroso, María
Goday Arnó, Albert
Ramos, Rafel
Marin-Ibanez, Alejandro
Jesús Guembe, María
Rigo, Fernando
José Tormo-Díaz, Maria
Moreno Iribas, Conchi
Josep Cabré, Joan
Segura, Antonio
Miguel Baena-Diez, Jose
Gómez de la Cámara, Agustín
Lapetra, José
Quesada, Miquel
Jose Medrano, Maria
Berjón, Jesús
Frontera, Guillem
Gavrila, Diana
Barricarte, Aurelio
Basora, Josep
María García, José
García-Lareo, Manel
Lora Pablos, David
Mayoral, Eduardo
Grau, Maria
Marrugat, Jaume, 1954-
Keywords: Malalties cardiovasculars
Cardiovascular diseases
Issue Date: 1-Feb-2018
Publisher: Elsevier
Abstract: The effect of above-normal body mass index (BMI) on health outcomes is controversial because it is difficult to distinguish from the effect due to BMI-associated cardiovascular risk factors. The objective was to analyze the impact on 10-year incidence of cardiovascular disease, cancer deaths and overall mortality of the interaction between cardiovascular risk factors and BMI. We conducted a pooled analysis of individual data from 12 Spanish population cohorts with 10-year follow-up. Participants had no previous history of cardiovascular diseases and were 35-79years old at basal examination. Body mass index was measured at baseline being the outcome measures ten-year cardiovascular disease, cancer and overall mortality. Multivariable analyses were adjusted for potential confounders, considering the significant interactions with cardiovascular risk factors. We included 54,446 individuals (46.5% with overweight and 27.8% with obesity). After considering the significant interactions, the 10-year risk of cardiovascular disease was significantly increased in women with overweight and obesity [Hazard Ratio=2.34 (95% confidence interval: 1.19-4.61) and 5.65 (1.54-20.73), respectively]. Overweight and obesity significantly increased the risk of cancer death in women [3.98 (1.53-10.37) and 11.61 (1.93-69.72)]. Finally, obese men had an increased risk of cancer death and overall mortality [1.62 (1.03-2.54) and 1.34 (1.01-1.76), respectively]. In conclusion, overweight and obesity significantly increased the risk of cancer death and of fatal and non-fatal cardiovascular disease in women; whereas obese men had a significantly higher risk of death for all causes and for cancer. Cardiovascular risk factors may act as effect modifiers in these associations.
Note: Versió postprint del document publicat a:
It is part of: Preventive Medicine, 2018, vol. 107, p. 81-89
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ISSN: 0091-7435
Appears in Collections:Articles publicats en revistes (Medicina)

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