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Title: | Vagus nerve stimulation as a potential modulator of periictal psychotic episodes: A report of four cases |
Author: | Alemany, Montse Real, Eva Custal, Núria Sala Padró, Jacint Rodríguez Bel, Laura Plans, Gerard Mora, Jaume Santurino, Mila Vancamp, Tim Falip, Mercè |
Keywords: | Psicosi Epilèpsia Nervi vague Psychoses Epilepsy Vagus nerve |
Issue Date: | 1-Jan-2021 |
Publisher: | Elsevier Inc. |
Abstract: | Drug resistant epilepsy (DRE) has been associated with a high incidence of psychotic disorders. Patients can develop psychosis after starting a new antiseizure medication, after undergoing resective surgery, or after implantation of a vagus nerve stimulation (VNS) system. The aim of this study was to investigate the modulation effect of VNS on psychotic episodes in DRE patients with a pre-existing history of periictal psychotic episodes (PPE). We retrospectively report the outcome of four patients from a single tertiary center with PPE prior to implantation. None of the implanted patients developed de novo PPE after VNS therapy. Regarding seizure outcome, all patients demonstrated a response to VNS with two who experienced who status epilepticus and three patients wtih a change in semiology with after VNS implantation. PPE disappeared in all the study patients, two of them at 6 months post-implantation and in the others after 2 and 3 years, respectively. 18F-FDG-PET results showed hypermetabolism in both anterior insular and medial frontal lobes which disappeared in the 18F -FDG-PET 4 years post-implantation. Based on the results of this series of cases we suggest that VNS therapy may be useful to modulatet PPE in patients with DRE, though effectiveness may be time-dependent. |
Note: | Reproducció del document publicat a: https://doi.org/10.1016/j.ebr.2021.100434 |
It is part of: | Epilepsy & Behavior Reports, 2021, vol. 15 |
URI: | http://hdl.handle.net/2445/178234 |
Related resource: | https://doi.org/10.1016/j.ebr.2021.100434 |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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1-s2.0-S2589986421000083-main.pdf | 2.83 MB | Adobe PDF | View/Open |
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