Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/178335
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Azoulay, Daniel | - |
dc.contributor.author | Ramos Rubio, Emilio | - |
dc.contributor.author | Casellas Robert, Margarida | - |
dc.contributor.author | Salloum, Chady | - |
dc.contributor.author | Lladó Garriga, Laura | - |
dc.contributor.author | Nadler, Roy | - |
dc.contributor.author | Busquets Barenys, Juli | - |
dc.contributor.author | Caula Freixa, Celia | - |
dc.contributor.author | Mils, Kristel | - |
dc.contributor.author | Lopez Ben, Santiago | - |
dc.contributor.author | Figueras Felip, Joan | - |
dc.contributor.author | Lim, Chetana | - |
dc.date.accessioned | 2021-06-14T07:46:22Z | - |
dc.date.issued | 2020-10-08 | - |
dc.identifier.issn | 0168-8278 | - |
dc.identifier.uri | http://hdl.handle.net/2445/178335 | - |
dc.description.abstract | Background & Aims: Liver resection (LR) in patients with hepatocellular carcinoma (HCC) and clinically significant portal hypertension (CSPH) defined as a hepatic venous pressure gradient (HVPG) >−10 mmHg is not encouraged. Here, we reap praised the outcomes of patients with cirrhosis and CSPH who underwent LR for HCC in highly specialised liver centres. Methods: This was a retrospective multicentre study from 1999 to 2019. Predictors for postoperative liver decompensation and textbook outcomes were identified. Results: In total, 79 patients with a median age of 65 years were included. The Child-Pugh grade was A in 99% of patients, and the median model for end-stage liver disease (MELD) score was 8. The median HVPG was 12 mmHg. Major hepatectomies and laparoscopies were performed in 28% and 34% of patients, respectively. Ninety-day mortality and severe morbidity rates were 6% and 27%, respectively. Postoperative and persistent liver decompensation occurred in 35% and 10% of patients at 3 months. Predictors of liver decompensation included increased preoperative HVPG (p = 0.004), increased serum total bilirubin (p = 0.02), and open approach (p = 0.03). Of the patients, 34% achieved a textbook outcome, of which the laparoscopic approach was the sole predictor (p = 0.004). The 5-year overall survival and recurrence-free survival rates were 55% and 43%, respectively. Conclusions: Patients with cirrhosis, HCC and HVPG >−10 mmHg can undergo LR with acceptable mortality, morbidity, and liver decompensation rates. The laparoscopic approach was the sole predictor of a textbook outcome. | - |
dc.format.extent | 8 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Elsevier | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1016/j.jhepr.2020.100190 | - |
dc.relation.ispartof | Journal of Hepatology, 2020, vol. 3, num. 100190 | - |
dc.relation.uri | https://doi.org/10.1016/j.jhepr.2020.100190 | - |
dc.rights | cc-by-nc-nd (c) Azoulay, Daniel et al., 2020 | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | - |
dc.source | Articles publicats en revistes (Ciències Clíniques) | - |
dc.subject.classification | Hepatectomia | - |
dc.subject.classification | Hipertensió portal | - |
dc.subject.classification | Període postoperatori | - |
dc.subject.classification | Cirrosi hepàtica | - |
dc.subject.other | Hepatectomy | - |
dc.subject.other | Portal hypertension | - |
dc.subject.other | Postoperative period | - |
dc.subject.other | Hepatic cirrhosis | - |
dc.title | Liver resection for hepatocellular carcinoma in patients with clinically significant portal hypertension | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 706527 | - |
dc.date.updated | 2021-06-14T07:46:22Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 26734627 | - |
dc.identifier.pmid | 33294830 | - |
Appears in Collections: | Articles publicats en revistes (Ciències Clíniques) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
706527.pdf | 561.52 kB | Adobe PDF | View/Open |
This item is licensed under a Creative Commons License