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Title: Adenosine Signaling in Mast Cells and Allergic Diseases.
Author: Garcia Garcia, Lucia
Olle, Laia
Martin, Margarita
Roca i Ferrer, Jordi
Muñoz Cano, Rosa Maria
Keywords: Al·lèrgia
Issue Date: 14-May-2021
Publisher: MDPI
Abstract: Adenosine is a nucleoside involved in the pathogenesis of allergic diseases. Its effects are mediated through its binding to G protein-coupled receptors: A1, A2a, A2b and A3. The receptors differ in the type of G protein they recruit, in the effect on adenylyl cyclase (AC) activity and the downstream signaling pathway triggered. Adenosine can produce both an enhancement and an inhibition of mast cell degranulation, indicating that adenosine effects on these receptors is controversial and remains to be clarified. Depending on the study model, A1, A2b, and A3 receptors have shown anti- or pro-inflammatory activity. However, most studies reported an anti-inflammatory activity of A2a receptor. The precise knowledge of the adenosine mechanism of action may allow to develop more efficient therapies for allergic diseases by using selective agonist and antagonist against specific receptor subtypes.
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It is part of: International Journal of Molecular Sciences, 2021, vol. 22, num. 10
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ISSN: 1661-6596
Appears in Collections:Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)
Articles publicats en revistes (Biomedicina)

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