Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/178411
Title: | Adenosine Signaling in Mast Cells and Allergic Diseases. |
Author: | Garcia Garcia, Lucia Olle, Laia Martín Andorrà, Margarita Roca i Ferrer, Jordi Muñoz Cano, Rosa Maria |
Keywords: | Al·lèrgia Adenosina Allergy Adenosine |
Issue Date: | 14-May-2021 |
Publisher: | MDPI |
Abstract: | Adenosine is a nucleoside involved in the pathogenesis of allergic diseases. Its effects are mediated through its binding to G protein-coupled receptors: A1, A2a, A2b and A3. The receptors differ in the type of G protein they recruit, in the effect on adenylyl cyclase (AC) activity and the downstream signaling pathway triggered. Adenosine can produce both an enhancement and an inhibition of mast cell degranulation, indicating that adenosine effects on these receptors is controversial and remains to be clarified. Depending on the study model, A1, A2b, and A3 receptors have shown anti- or pro-inflammatory activity. However, most studies reported an anti-inflammatory activity of A2a receptor. The precise knowledge of the adenosine mechanism of action may allow to develop more efficient therapies for allergic diseases by using selective agonist and antagonist against specific receptor subtypes. |
Note: | Reproducció del document publicat a: https://doi.org/10.3390/ijms22105203 |
It is part of: | International Journal of Molecular Sciences, 2021, vol. 22, num. 10 |
URI: | http://hdl.handle.net/2445/178411 |
Related resource: | https://doi.org/10.3390/ijms22105203 |
ISSN: | 1661-6596 |
Appears in Collections: | Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) Articles publicats en revistes (Biomedicina) |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
712597.pdf | 10.05 MB | Adobe PDF | View/Open |
This item is licensed under a Creative Commons License