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Title: Systemic AA amyloidosis caused by inflammatory hepatocellular adenoma
Author: Calderaro, Julien
Letouzé, Eric
Bayard, Quentin
Boulai, Anais
Renault, Victor
Deleuze, Jean-François
Bestard Matamoros, Oriol
Franco, Dominique
Zafrani, Elie-Serge
Nault, Jean-Charles
Moutschen, Michel
Zucman-Rossi, Jessica
Keywords: Fetge
Issue Date: 20-Sep-2018
Publisher: Massachusetts Medical Society
Abstract: To the Editor: Amyloid A (AA) systemic amyloidosis is a complication of chronic inflammatory diseases that is caused by the deposition of insoluble aggregates of cleaved N-terminal fragments of serum amyloid A (SAA) protein in tissues and organs throughout the body. Under physiologic conditions, SAA protein is produced by hepatocytes during the acute inflammatory phase in response to various cytokines such as interleukin-6. SAA is also overexpressed by neoplastic hepatocytes in inflammatory hepatocellular adenomas, a specific molecular subtype of benign liver tumors.
Note: Reproducció del document publicat a:
It is part of: New England Journal of Medicine, 2018, vol. 379, num. 12, p. 1178-1180
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ISSN: 0028-4793
Appears in Collections:Articles publicats en revistes (Ciències Clíniques)

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