Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/178514
Title: Diagnostic delay of associated interstitial lung disease increases mortality in rheumatoid arthritis
Author: Cano Jiménez, Esteban
Vázquez Rodríguez, Tomás
Martín Robles, Irene
Castillo Villegas, Diego
Juan García, Javier
Bollo de Miguel, Elena
Robles-Pérez, Alejandro
Ferrer Galván, Marta
Mouronte Roibas, Cecilia
Herrera Lara, Susana
Bermudo, Guadalupe
García Moyano, Marta
Rodríguez Portal, Jose Antonio
Sellarés Torres, Jacobo
Narváez, Javier
Molina Molina, María
Keywords: Malalties dels pulmons
Artritis reumatoide
Mortalitat
Pulmonary diseases
Rheumatoid arthritis
Mortality
Issue Date: 28-Apr-2021
Publisher: Springer Nature
Abstract: Rheumatoid arthritis (RA) is a systemic autoimmune disease whose main extra-articular organ affected is the lung, sometimes in the form of diffuse interstitial lung disease (ILD) and conditions the prognosis. A multicenter, observational, descriptive and cross-sectional study of consecutive patients diagnosed with RA-ILD. Demographic, analytical, respiratory functional and evolution characteristics were analyzed to evaluate the predictors of progression and mortality. 106 patients were included. The multivariate analysis showed that the diagnostic delay was an independent predictor of mortality (HR 1.11, CI 1.01-1.23, p = 0.035). Also, age (HR 1.33, 95% CI 1.09-1.62, p = 0.0045), DLCO (%) (HR 0.85, 95% CI 0.73-0.98, p = 0.0246), and final SatO2 (%) in the 6MWT (HR 0.62, 95% CI 0.39-0.99, p = 0.0465) were independent predictor variables of mortality, as well as GAP index (HR 4.65, 95% CI 1.59-13.54, p = 0.0051) and CPI index (HR 1.12, 95% CI 1.03-1.22, p = 0.0092). The withdrawal of MTX or LFN after ILD diagnosis was associated with disease progression in the COX analysis (HR 2.18, 95% CI 1.14-4.18, p = 0.019). This is the first study that highlights the diagnostic delay in RA-ILD is associated with an increased mortality just like happens in IPF.
Note: Reproducció del document publicat a: https://doi.org/10.1038/s41598-021-88734-2
It is part of: Scientific Reports, 2021, vol. 11
URI: http://hdl.handle.net/2445/178514
Related resource: https://doi.org/10.1038/s41598-021-88734-2
Appears in Collections:Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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