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http://hdl.handle.net/2445/178638
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DC Field | Value | Language |
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dc.contributor.author | Sáinz Jaspeado, Miguel Guillermo | - |
dc.contributor.author | Martín Liberal, Juan Jesús | - |
dc.contributor.author | Lagares Tena, Laura | - |
dc.contributor.author | Mateo Lozano, Silvia | - |
dc.contributor.author | García del Muro Solans, Xavier | - |
dc.contributor.author | Tirado, Oscar M. | - |
dc.date.accessioned | 2021-06-23T14:37:22Z | - |
dc.date.available | 2021-06-23T14:37:22Z | - |
dc.date.issued | 2011-04-01 | - |
dc.identifier.issn | 1949-2553 | - |
dc.identifier.uri | http://hdl.handle.net/2445/178638 | - |
dc.description.abstract | Sarcomas represent a heterogeneous group of tumors with a complex and difficult reproducible classification. Their pathogenesis is poorly understood and there are few effective treatment options for advanced disease. Caveolin-1 is a multifunctional scaffolding protein with multiple binding partners that regulates multiple cancer-associated processes including cellular transformation, tumor growth, cell death and survival, multidrug resistance, angiogenesis, cell migration and metastasis. However, ambiguous roles have been ascribed to caveolin-1 in signal transduction and cancer, including sarcomas. In particular, evidence indicating that caveolin-1 function is cell context dependent has been repeatedly reported. Caveolin-1 appears to act as a tumor suppressor protein at early stages of cancer progression. In contrast, a growing body of evidence indicates that caveolin-1 is up-regulated in several multidrug-resistant and metastatic cancer cell lines and human tumor specimens. This review is focused on the role of caveolin-1 in several soft tissue and bone sarcomas and discusses the use of this protein as a potential diagnostic and prognostic marker and as a therapeutic target. | - |
dc.format.extent | 8 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Impact Journals | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.18632/oncotarget.255 | - |
dc.relation.ispartof | Oncotarget, 2011, vol. 2, num. 4, p. 305-312 | - |
dc.relation.uri | https://doi.org/10.18632/oncotarget.255 | - |
dc.rights | cc-by (c) Sáinz Jaspeado, Miguel Guillermo et al., 2011 | - |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | - |
dc.source | Articles publicats en revistes (Ciències Clíniques) | - |
dc.subject.classification | Fisiologia | - |
dc.subject.classification | Sarcoma | - |
dc.subject.classification | Diagnòstic | - |
dc.subject.classification | Etiologia | - |
dc.subject.other | Physiology | - |
dc.subject.other | Sarcoma | - |
dc.subject.other | Diagnosis | - |
dc.subject.other | Etiology | - |
dc.title | Caveolin-1 in sarcomas: friend or foe? | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 680008 | - |
dc.date.updated | 2021-06-23T14:37:22Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 21471610 | - |
Appears in Collections: | Articles publicats en revistes (Ciències Clíniques) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
Files in This Item:
File | Description | Size | Format | |
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680008.pdf | 1.08 MB | Adobe PDF | View/Open |
This item is licensed under a Creative Commons License