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http://hdl.handle.net/2445/178639
Title: | Cryopreservation of unrelated donor hematopoietic stem cells: the right answer for transplantations during the COVID-19 pandemic? |
Author: | Fernández Sojo, Jesus Azqueta, Carmen Valdivia, Elena Martorell, Lluis Medina Boronat, Laura Martínez Llonch, Nuria Torrents, Silvia Codinach, Margarita Canals, Carme Elorza, Izaskun Parody, Rocío Martino, Rodrigo Trabazo, Maria Díaz de Heredia, Cristina Ferra, Christelle Valcárcel, David Linares, Mónica Ancochea, Àgueda García Rey, Enric García Muñoz, Nadia Medina, Laura Castillo, Nerea Carreras, Enric Villa, Juliana Querol Giner, Sergi |
Keywords: | COVID-19 Cèl·lules mare COVID-19 Stem cells |
Issue Date: | 14-Jun-2021 |
Publisher: | Springer Nature |
Abstract: | Cryopreservation was recommended to ensure continuity of unrelated donor (UD) hematopoietic stem cell transplantation (HSCT) during COVID-19 pandemic. However, its impact on clinical outcomes and feasibility was not well known. We compared 32 patients who underwent UD HSCT using cryopreserved peripheral blood stem cells (PBSC) during the COVID-19 pandemic with 32 patients who underwent UD HSCT using fresh PBSC in the previous period. Median neutrophil engraftment was 17.5 and 17.0 days with cryopreserved and fresh grafts, respectively. Non-significant delays were found in platelet recovery days (25.5 versus 19.0; P = 0.192) and full donor chimerism days (35.0 and 31.5; P = 0.872) using cryopreserved PBSC. The rate of acute graft-versus-host disease at 100 days was 41% (95% CI [21-55%]) in cryopreserved group versus 31% (95% CI [13-46%]) in fresh group (P = 0.380). One-hundred days progression-relapse free survival and overall survival did not differ significantly. During COVID-19 pandemic, six frozen UD donations were not transfused and logistical and clinical issues regarding cryopreservation procedure, packaging, and transporting appeared. In summary, UD HSCT with cryopreserved PBSC was safe during this challenging time. More efforts are needed to ensure that all frozen grafts are transplanted and cryopreservation requirements are harmonized. |
Note: | Reproducció del document publicat a: https://doi.org/10.1038/s41409-021-01367-x |
It is part of: | Bone Marrow Transplantation, 2021 |
URI: | http://hdl.handle.net/2445/178639 |
Related resource: | https://doi.org/10.1038/s41409-021-01367-x |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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File | Description | Size | Format | |
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Cryopreservation of unrelated donor hematopoietic stem cells.pdf | 697.47 kB | Adobe PDF | View/Open |
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