Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/178667
Title: | 2-[18F]FDG PET/CT as a Predictor of Microvascular Invasion and High Histological Grade in Patients with Hepatocellular Carcinoma |
Author: | Sabaté Llobera, Aida Mestres Martí, Judit Reynés-Llompart, Gabriel Lladó Garriga, Laura Mils, Kristel Serrano Piñol, M. Teresa Cortés Romera, Montserrat Bertran Rodríguez, Esther Fabregat Romero, Isabel Ramos Rubio, Emilio |
Keywords: | Tumors Pronòstic mèdic Tumors Prognosis |
Issue Date: | 23-May-2021 |
Publisher: | MDPI AG |
Abstract: | Hepatocellular carcinoma (HCC) generally presents a low avidity for 2-deoxy-2-[18F]fluoro-d-glucose (FDG) in PET/CT although an increased FDG uptake seems to relate to more aggressive biological factors. To define the prognostic value of PET/CT with FDG in patients with an HCC scheduled for a tumor resection, forty-one patients were prospectively studied. The histological factors of a poor prognosis were determined and FDG uptake in the HCC lesions was analyzed semi-quantitatively (lean body mass-corrected standardized uptake value (SUL) and tumor-to-liver ratio (TLR) at different time points). The PET metabolic parameters were related to the histological characteristics of the resected tumors and to the evolution of patients. Microvascular invasion (MVI) and a poor grade of differentiation were significantly related to a worse prognosis. The SULpeak of the lesion 60 min post-FDG injection was the best parameter to predict MVI while the SULpeak of the TLR at 60 min was better for a poor differentiation. Moreover, the latter parameter was also the best preoperative variable available to predict any of these two histological factors. Patients with an increased TLRpeak60 presented a significantly higher incidence of poor prognostic factors than the rest (75% vs. 28.6%, p = 0.005) and a significantly higher incidence of recurrence at 12 months (38% vs. 0%, p = 0.014). Therefore, a semi-quantitative analysis of certain metabolic parameters on PET/CT can help identify, preoperatively, patients with histological factors of a poor prognosis, allowing an adjustment of the therapeutic strategy for those patients with a higher risk of an early recurrence. |
Note: | Reproducció del document publicat a: https://doi.org/10.3390/cancers13112554 |
It is part of: | Cancers, 2021, vol. 13, issue. 11 |
URI: | http://hdl.handle.net/2445/178667 |
Related resource: | https://doi.org/10.3390/cancers13112554 |
Appears in Collections: | Articles publicats en revistes (Ciències Clíniques) Articles publicats en revistes (Medicina) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
cancers-13-02554.pdf | 4.84 MB | Adobe PDF | View/Open |
This item is licensed under a Creative Commons License