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http://hdl.handle.net/2445/178739
Title: | Mechanosensing at integrin-mediated cell–matrix adhesions: from molecular to integrated mechanisms |
Author: | Gauthier, Nils C. Roca-Cusachs Soulere, Pere |
Keywords: | Integrines Regulació cel·lular Integrins Cellular control mechanisms |
Issue Date: | 6-Feb-2018 |
Publisher: | Elsevier |
Abstract: | Integrin-mediated adhesions between cells and the extracellular matrix are fundamental for cell function, and one of their main roles is to sense and respond to mechanical force. Here we discuss the different mechanisms that can confer mechanosensitivity to adhesions. We first address molecular mechanisms mediated by force-induced changes in molecular properties, such as binding dynamics or protein conformation. Then, we discuss recent evidence on how these mechanisms are integrated with cellular and extracellular parameters such as myosin and actin activity, membrane tension, and ECM properties, endowing cells with an exquisite ability to both detect and respond to physical and mechanical cues from their environment. |
Note: | Versió postprint del document publicat a: https://doi.org/10.1016/j.ceb.2017.12.014 |
It is part of: | Current Opinion in Cell Biology, 2018, vol. 50, p. 20-26, |
URI: | http://hdl.handle.net/2445/178739 |
Related resource: | https://doi.org/10.1016/j.ceb.2017.12.014 |
DOI: | https://doi.org/10.1016/j.ceb.2017.12.014 |
ISSN: | 0955-0674 |
Appears in Collections: | Articles publicats en revistes (Institut de Bioenginyeria de Catalunya (IBEC)) |
Files in This Item:
File | Description | Size | Format | |
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gauthier and roca-cusachs preprint.pdf | 862.5 kB | Adobe PDF | View/Open | |
L17_2018_Current Opinion in Cell Biology_50_20.pdf | 1.19 MB | Adobe PDF | View/Open |
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