Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/178783
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Mattesen, Trine B. | - |
dc.contributor.author | Rasmussen, Mads H. | - |
dc.contributor.author | Sandoval, Juan | - |
dc.contributor.author | Ongen, Halit | - |
dc.contributor.author | Árnadóttir, Sigrid S. | - |
dc.contributor.author | Gladov, Josephine | - |
dc.contributor.author | Martínez Cardús, Anna | - |
dc.contributor.author | Castro de Moura, Manuel | - |
dc.contributor.author | Madsen, Anders H. | - |
dc.contributor.author | Laurberg, Søren | - |
dc.contributor.author | Dermitzakis, Emmanouil T. | - |
dc.contributor.author | Esteller, Manel | - |
dc.contributor.author | Andersen, Claus L. | - |
dc.contributor.author | Bramsen, Jesper B. | - |
dc.date.accessioned | 2021-07-05T10:16:07Z | - |
dc.date.available | 2021-07-05T10:16:07Z | - |
dc.date.issued | 2020-04-24 | - |
dc.identifier.issn | 2041-1723 | - |
dc.identifier.uri | http://hdl.handle.net/2445/178783 | - |
dc.description.abstract | Transcriptional characterization and classification has potential to resolve the inter-tumor heterogeneity of colorectal cancer and improve patient management. Yet, robust transcriptional profiling is difficult using formalin-fixed, paraffin-embedded (FFPE) samples, which complicates testing in clinical and archival material. We present MethCORR, an approach that allows uniform molecular characterization and classification of fresh-frozen and FFPE samples. MethCORR identifies genome-wide correlations between RNA expression and DNA methylation in fresh-frozen samples. This information is used to infer gene expression information in FFPE samples from their methylation profiles. MethCORR is here applied to methylation profiles from 877 fresh-frozen/FFPE samples and comparative analysis identifies the same two subtypes in four independent cohorts. Furthermore, subtype-specific prognostic biomarkers that better predicts relapse-free survival (HR = 2.66, 95%CI [1.67-4.22], P value < 0.001 (log-rank test)) than UICC tumor, node, metastasis (TNM) staging and microsatellite instability status are identified and validated using DNA methylation-specific PCR. The MethCORR approach is general, and may be similarly successful for other cancer types. | - |
dc.format.extent | 15 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Nature Publishing Group | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1038/s41467-020-16000-6 | - |
dc.relation.ispartof | Nature Communications, 2020, vol. 11, num. 2025 | - |
dc.relation.uri | https://doi.org/10.1038/s41467-020-16000-6 | - |
dc.rights | cc-by (c) Mattesen, Trine B. et al., 2020 | - |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | - |
dc.source | Articles publicats en revistes (Ciències Fisiològiques) | - |
dc.subject.classification | Càncer colorectal | - |
dc.subject.classification | Genètica quantitativa | - |
dc.subject.classification | Pronòstic mèdic | - |
dc.subject.other | Colorectal cancer | - |
dc.subject.other | Quantitative genetics | - |
dc.subject.other | Prognosis | - |
dc.title | MethCORR Modelling of Methylomes From Formalin-Fixed Paraffin-Embedded Tissue Enables Characterization and Prognostication of Colorectal Cancer | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 700369 | - |
dc.date.updated | 2021-07-05T10:16:08Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 32332866 | - |
Appears in Collections: | Articles publicats en revistes (Ciències Fisiològiques) |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
700369.pdf | 2.99 MB | Adobe PDF | View/Open | |
702375.pdf | Publisher Correction | 483.52 kB | Adobe PDF | View/Open |
This item is licensed under a Creative Commons License