Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/178834
Title: Characterizing the Invasive Tumor Front of Aggressive Uterine Adenocarcinoma and Leiomyosarcoma
Author: Sanegre, Sabina
Eritja, Núria
Andrea, Carlos de
Diaz Martin, Juan
Diaz Lagares, Ángel
Jácome, María Amalia
Salguero Aranda, Carmen
García Ros, David
Davidson, Ben
Lopez, Rafel
Melero, Ignacio
Navarro, Samuel
Ramon y Cajal, Santiago
Alava, Enrique de
Matias Guiu, Xavier
Noguera, Rosa
Keywords: Metàstasi
Càncer d'úter
Epigenètica
Metastasis
Uterine cancer
Epigenetics
Issue Date: 3-Jun-2021
Publisher: Frontiers Media SA
Abstract: The invasive tumor front (the tumor-host interface) is vitally important in malignant cell progression and metastasis. Tumor cell interactions with resident and infiltrating host cells and with the surrounding extracellular matrix and secreted factors ultimately determine the fate of the tumor. Herein we focus on the invasive tumor front, making an in-depth characterization of reticular fiber scaffolding, infiltrating immune cells, gene expression, and epigenetic profiles of classified aggressive primary uterine adenocarcinomas (24 patients) and leiomyosarcomas (11 patients). Sections of formalin-fixed samples before and after microdissection were scanned and studied. Reticular fiber architecture and immune cell infiltration were analyzed by automatized algorithms in colocalized regions of interest. Despite morphometric resemblance between reticular fibers and high presence of macrophages, we found some variance in other immune cell populations and distinctive gene expression and cell adhesion-related methylation signatures. Although no evident overall differences in immune response were detected at the gene expression and methylation level, impaired antimicrobial humoral response might be involved in uterine leiomyosarcoma spread. Similarities found at the invasive tumor front of uterine adenocarcinomas and leiomyosarcomas could facilitate the use of common biomarkers and therapies. Furthermore, molecular and architectural characterization of the invasive front of uterine malignancies may provide additional prognostic information beyond established prognostic factors.
Note: Reproducció del document publicat a: https://doi.org/10.3389/fcell.2021.670185
It is part of: Frontiers in Cell and Developmental Biology, 2021, vol. 9, num. 670185
URI: http://hdl.handle.net/2445/178834
Related resource: https://doi.org/10.3389/fcell.2021.670185
Appears in Collections:Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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