Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/178864
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dc.contributor.authorRustad, Even H.-
dc.contributor.authorYellapantula, Venkata-
dc.contributor.authorLeongamornlert, Daniel-
dc.contributor.authorBolli, Niccolò-
dc.contributor.authorLedergor, Guy-
dc.contributor.authorNadeu, Ferran-
dc.contributor.authorAngelopoulos, Nicos-
dc.contributor.authorDawson, Kevin J.-
dc.contributor.authorMitchell, Thomas J.-
dc.contributor.authorOsborne, Robert J.-
dc.contributor.authorZiccheddu, Bachisio-
dc.contributor.authorCarniti, Cristiana-
dc.contributor.authorMontefusco, Vittorio-
dc.contributor.authorCorradini, Paolo-
dc.contributor.authorAnderson, Kenneth C.-
dc.contributor.authorMoreau, Philippe-
dc.contributor.authorPapaemmanuil, Elli-
dc.contributor.authorAlexandrov, Ludmil B.-
dc.contributor.authorPuente, Xose S.-
dc.contributor.authorCampo Güerri, Elias-
dc.contributor.authorSiebert, Reiner-
dc.contributor.authorAvet Loiseau, Herve-
dc.contributor.authorLandgren, Ola-
dc.contributor.authorMunshi, Nikhil-
dc.contributor.authorCampbell, Peter J.-
dc.contributor.authorMaura, Francesco-
dc.date.accessioned2021-07-06T14:34:23Z-
dc.date.available2021-07-06T14:34:23Z-
dc.date.issued2020-04-21-
dc.identifier.issn2041-1723-
dc.identifier.urihttp://hdl.handle.net/2445/178864-
dc.description.abstractThe evolution and progression of multiple myeloma and its precursors over time is poorly understood. Here, we investigate the landscape and timing of mutational processes shaping multiple myeloma evolution in a large cohort of 89 whole genomes and 973 exomes. We identify eight processes, including a mutational signature caused by exposure to melphalan. Reconstructing the chronological activity of each mutational signature, we estimate that the initial transformation of a germinal center B-cell usually occurred during the first 2nd-3rd decades of life. We define four main patterns of activation-induced deaminase (AID) and apolipoprotein B mRNA editing catalytic polypeptide-like (APOBEC) mutagenesis over time, including a subset of patients with evidence of prolonged AID activity during the premalignant phase, indicating antigen-responsiveness and germinal center reentry. Our findings provide a framework to study the etiology of multiple myeloma and explore strategies for prevention and early detection.-
dc.format.extent14 p.-
dc.format.mimetypeapplication/pdf-
dc.language.isoeng-
dc.publisherNature Publishing Group-
dc.relation.isformatofReproducció del document publicat a: https://doi.org/10.1038/s41467-020-15740-9-
dc.relation.ispartofNature Communications, 2020, vol. 11, num. 1917-
dc.relation.urihttps://doi.org/10.1038/s41467-020-15740-9-
dc.rightscc-by (c) Rustad, Even H. et al., 2020-
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/-
dc.subject.classificationMieloma múltiple-
dc.subject.classificationEtiologia-
dc.subject.otherMultiple myeloma-
dc.subject.otherEtiology-
dc.titleTiming the initiation of multiple myeloma.-
dc.typeinfo:eu-repo/semantics/article-
dc.typeinfo:eu-repo/semantics/publishedVersion-
dc.identifier.idgrec701493-
dc.date.updated2021-07-06T14:34:23Z-
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/H2020/817997/EU//bECOMiNG-
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess-
dc.identifier.pmid32317634-
Appears in Collections:Publicacions de projectes de recerca finançats per la UE
Articles publicats en revistes (Fonaments Clínics)

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