Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/178864
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DC Field | Value | Language |
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dc.contributor.author | Rustad, Even H. | - |
dc.contributor.author | Yellapantula, Venkata | - |
dc.contributor.author | Leongamornlert, Daniel | - |
dc.contributor.author | Bolli, Niccolò | - |
dc.contributor.author | Ledergor, Guy | - |
dc.contributor.author | Nadeu, Ferran | - |
dc.contributor.author | Angelopoulos, Nicos | - |
dc.contributor.author | Dawson, Kevin J. | - |
dc.contributor.author | Mitchell, Thomas J. | - |
dc.contributor.author | Osborne, Robert J. | - |
dc.contributor.author | Ziccheddu, Bachisio | - |
dc.contributor.author | Carniti, Cristiana | - |
dc.contributor.author | Montefusco, Vittorio | - |
dc.contributor.author | Corradini, Paolo | - |
dc.contributor.author | Anderson, Kenneth C. | - |
dc.contributor.author | Moreau, Philippe | - |
dc.contributor.author | Papaemmanuil, Elli | - |
dc.contributor.author | Alexandrov, Ludmil B. | - |
dc.contributor.author | Puente, Xose S. | - |
dc.contributor.author | Campo Güerri, Elias | - |
dc.contributor.author | Siebert, Reiner | - |
dc.contributor.author | Avet-Loiseau, Hervé | - |
dc.contributor.author | Landgren, Ola | - |
dc.contributor.author | Munshi, Nikhil | - |
dc.contributor.author | Campbell, Peter J. | - |
dc.contributor.author | Maura, Francesco | - |
dc.date.accessioned | 2021-07-06T14:34:23Z | - |
dc.date.available | 2021-07-06T14:34:23Z | - |
dc.date.issued | 2020-04-21 | - |
dc.identifier.issn | 2041-1723 | - |
dc.identifier.uri | http://hdl.handle.net/2445/178864 | - |
dc.description.abstract | The evolution and progression of multiple myeloma and its precursors over time is poorly understood. Here, we investigate the landscape and timing of mutational processes shaping multiple myeloma evolution in a large cohort of 89 whole genomes and 973 exomes. We identify eight processes, including a mutational signature caused by exposure to melphalan. Reconstructing the chronological activity of each mutational signature, we estimate that the initial transformation of a germinal center B-cell usually occurred during the first 2nd-3rd decades of life. We define four main patterns of activation-induced deaminase (AID) and apolipoprotein B mRNA editing catalytic polypeptide-like (APOBEC) mutagenesis over time, including a subset of patients with evidence of prolonged AID activity during the premalignant phase, indicating antigen-responsiveness and germinal center reentry. Our findings provide a framework to study the etiology of multiple myeloma and explore strategies for prevention and early detection. | - |
dc.format.extent | 14 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Nature Publishing Group | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1038/s41467-020-15740-9 | - |
dc.relation.ispartof | Nature Communications, 2020, vol. 11, num. 1917 | - |
dc.relation.uri | https://doi.org/10.1038/s41467-020-15740-9 | - |
dc.rights | cc-by (c) Rustad, Even H. et al., 2020 | - |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | - |
dc.source | Articles publicats en revistes (Fonaments Clínics) | - |
dc.subject.classification | Mieloma múltiple | - |
dc.subject.classification | Etiologia | - |
dc.subject.other | Multiple myeloma | - |
dc.subject.other | Etiology | - |
dc.title | Timing the initiation of multiple myeloma. | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 701493 | - |
dc.date.updated | 2021-07-06T14:34:23Z | - |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/H2020/817997/EU//bECOMiNG | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 32317634 | - |
Appears in Collections: | Articles publicats en revistes (Fonaments Clínics) Publicacions de projectes de recerca finançats per la UE |
Files in This Item:
File | Description | Size | Format | |
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701493.pdf | 3.5 MB | Adobe PDF | View/Open |
This item is licensed under a Creative Commons License