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Title: | Patterns of change in treatment, response, and outcome in patients with follicular lymphoma over the last four decades: a single-center experience. |
Author: | Mozas, Pablo Nadeu, Ferran Rivas Delgado, Alfredo Rivero, Andrea Garrote, Marta Balagué Ponz, Olga González Farré, Blanca Veloza, Luis Baumann, Tycho Giné Soca, Eva Delgado, Julio (Delgado González) Villamor i Casas, Neus Campo Güerri, Elias Magnano, Laura López Guillermo, Armando |
Keywords: | Immunoteràpia Limfomes Immunotheraphy Lymphomas |
Issue Date: | 5-Mar-2020 |
Publisher: | Springer Nature |
Abstract: | Although the introduction of immunotherapy has improved outcomes for follicular lymphoma (FL) patients, histological transformation (HT) and early relapse still confer a poor prognosis. We sought to describe the patterns of change in treatment, response, and outcome of FL patients at our institution over the last four decades. Seven hundred and twenty-seven patients (389 F/338 M; median age, 57 years) consecutively diagnosed with grade 1-3a FL between 1980 and 2017, categorized into four decades according to the time of diagnosis, constituted the study population. Clinical characteristics, treatment, response, absolute and relative survival, HT, second malignancies (SM), and causes of death were assessed. Median OS for the entire cohort was 17.6 years. From decade 1 to 4, there was an increase in the complete response rate (48 to 70%), progression-free survival (40 to 56% at 5 years), OS (77 to 86% at 5 years), and relative survival ratio (0.83 to 0.94 at 5 years), with no significant differences in the risk of HT or SM. Lymphoma remained the most common cause of death in all four decades. These findings illustrate the overall improvement in outcome for FL patients, but support the need for further research into risk stratification and management. |
Note: | Reproducció del document publicat a: https://doi.org/10.1038/s41408-020-0299-0 |
It is part of: | Blood Cancer Journal, 2020, vol. 10, num. 31 |
URI: | http://hdl.handle.net/2445/178866 |
Related resource: | https://doi.org/10.1038/s41408-020-0299-0 |
ISSN: | 2044-5385 |
Appears in Collections: | Articles publicats en revistes (Fonaments Clínics) |
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