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Title: Migración de neutrófilos en larvas de pez cebra expuestos a extractos de sofrito de tomate
Author: Arteaga, Cristina
Bustillos Ortiz, Alcides Alberto
Gómez Catalán, Jesús
Keywords: Peix zebra
Cuina mediterrània
Agents antiinflamatoris
Zebra danio
Mediterranean cooking
Antiinflammatory agents
Issue Date: 2020
Publisher: Sociedad Latinoamericana de Nutrición
Abstract: Neutrophils migration in zebrafish larvae exposed to tomato sofrito extracts. The main of this study was to evaluate the anti-inflammatory activity of tomato sofrito extracts, as well as standard compounds present in the Mediterranean diet, using an optimized experimental model based on zebrafish larvae. Neutrophil migration in zebrafish larvae 96 hours post fertilization was induced by a cut in the caudal fin and enhanced by adding lipopolysaccharide and was visualized and quantified by image analysis. The anti-inflammatory effect of tomato extract and the compounds used was correlated by the percentage decrease in the migration of neutrophils. The results showed that, tomato extract showed a reduction in neutrophil migration of 40% compared to the control group. Moreover, chlorogenic acid and cyanidin present in tomato sofrito sauce showed a decrease in neutrophil migration of 66.7% and 62.5% respectively. These percentages are comparable to the results observed in trials with anti-inflammatory drugs such as indomethacin and piroxicam. The results show that tomato sofrito extract has possible anti-inflammatory activity demonstrated by the reduction of neutrophil migration, furthermore the model was sensitive and valid to be applied in complex food matrices.
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It is part of: Archivos Latinoamericanos de Nutrición, 2020, vol. 70, num. 3, p. 182-190
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ISSN: 0004-0622
Appears in Collections:Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)

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