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http://hdl.handle.net/2445/178993
Title: | BAFF, APRIL and BAFFR on the pathogenesis of Immunoglobulin-A vasculitis |
Author: | Prieto Peña, Diana Genre, Fernanda Remuzgo Martínez, Sara Pulito Cueto, Verónica Atienza Mateo, Belén Llorca, Javier Sevilla Pérez, Belén Ortego Centeno, Norberto Lera Gómez, Leticia Leonardo, María Teresa Peñalba, Ana Narváez García, Francisco Javier Martín Penagos, Luis Rodrigo, Emilio Miranda Filloy, José A. Caminal Montero, Luis Collado, Paz Sánchez Pérez, Javier Argila, Diego de Rubio, Esteban Luque, Manuel León Blanco Madrigal, Juan María Galíndez Agirregoikoa, Eva Gualillo, Oreste Martín, Javier Castañeda, Santos Blanco, Ricardo González Gay, Miguel A. López Mejías, Raquel |
Keywords: | Immunoglobulines Vasculitis Malalties autoimmunitàries Immunoglobulins Vasculitis Autoimmune diseases |
Issue Date: | 1-Jun-2021 |
Publisher: | Springer Science and Business Media LLC |
Abstract: | BAFF, APRIL and BAFF-R are key proteins involved in the development of B-lymphocytes and autoimmunity. Additionally, BAFF, APRIL and BAFFR polymorphisms were associated with immune-mediated conditions, being BAFF GCTGT>A a shared insertion-deletion genetic variant for several autoimmune diseases. Accordingly, we assessed whether BAFF, APRIL and BAFFR represent novel genetic risk factors for Immunoglobulin-A vasculitis (IgAV), a predominantly B-lymphocyte inflammatory condition. BAFF rs374039502, which colocalizes with BAFF GCTGT>A, and two tag variants within APRIL (rs11552708 and rs6608) and BAFFR (rs7290134 and rs77874543) were genotyped in 386 Caucasian IgAV patients and 806 matched healthy controls. No genotypes or alleles differences were observed between IgAV patients and controls when BAFF, APRIL and BAFFR variants were analysed independently. Likewise, no statistically significant differences were found in the genotype and allele frequencies of BAFF, APRIL or BAFFR when IgAV patients were stratified according to the age at disease onset or to the presence/absence of gastrointestinal (GI) or renal manifestations. Similar results were disclosed when APRIL and BAFFR haplotypes were compared between IgAV patients and controls and between IgAV patients stratified according to the clinical characteristics mentioned above. Our results suggest that BAFF, APRIL and BAFFR do not contribute to the genetic network underlying IgAV. |
Note: | Reproducció del document publicat a: https://doi.org/10.1038/s41598-021-91055-z |
It is part of: | Scientific Reports, 2021, vol. 11, num. 11510 |
URI: | http://hdl.handle.net/2445/178993 |
Related resource: | https://doi.org/10.1038/s41598-021-91055-z |
ISSN: | 2045-2322 |
Appears in Collections: | Publicacions de projectes de recerca finançats per la UE Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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