Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/178996
Title: Lack of astrocytic glycogen alters synaptic plasticity but not seizure susceptibility
Author: Duran, Jordi
Brewer, M. Kathryn
Hervera Abad, Arnau
Gruart, Agnès
Río Fernández, José Antonio del
Delgado García, José M.
Guinovart, Joan J. (Joan Josep), 1947-
Keywords: Glicogen
Epilèpsia
Astròcits
Metabolisme
Glycogen
Epilepsy
Astrocytes
Metabolism
Issue Date: 8-Aug-2020
Publisher: Springer Nature
Abstract: Brain glycogen is mainly stored in astrocytes. However, recent studies both in vitro and in vivo indicate that glycogen also plays important roles in neurons. By conditional deletion of glycogen synthase (GYS1), we previously developed a mouse model entirely devoid of glycogen in the central nervous system (GYS1Nestin-KO). These mice displayed altered electrophysiological properties in the hippocampus and increased susceptibility to kainate-induced seizures. To understand which of these functions are related to astrocytic glycogen, in the present study, we generated a mouse model in which glycogen synthesis is eliminated specifically in astrocytes (GYS1Gfap-KO). Electrophysiological recordings of awake behaving mice revealed alterations in input/output curves and impaired long-term potentiation, similar, but to a lesser extent, to those obtained with GYS1Nestin-KO mice. Surprisingly, GYS1Gfap-KO mice displayed no change in susceptibility to kainate-induced seizures as determined by fEPSP recordings and video monitoring. These results confirm the importance of astrocytic glycogen in synaptic plasticity.
Note: Versió postprint del document publicat a: https://doi.org/10.1007/s12035-020-02055-5
It is part of: Molecular Neurobiology, 2020, vol. 57, num. 11, p. 4657-4666
URI: http://hdl.handle.net/2445/178996
Related resource: https://doi.org/10.1007/s12035-020-02055-5
ISSN: 0893-7648
Appears in Collections:Articles publicats en revistes (Biologia Cel·lular, Fisiologia i Immunologia)
Articles publicats en revistes (Institut de Neurociències (UBNeuro))
Articles publicats en revistes (Institut de Recerca Biomèdica (IRB Barcelona))
Articles publicats en revistes (Institut de Bioenginyeria de Catalunya (IBEC))

Files in This Item:
File Description SizeFormat 
708039.pdf717.96 kBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.