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dc.contributor.authorMurru, Andrea-
dc.contributor.authorVerdolini, Norma-
dc.contributor.authorAnmella, Gerard-
dc.contributor.authorPacchiarotti, Isabella-
dc.contributor.authorSamalin, Ludovic-
dc.contributor.authorAedo, Alberto-
dc.contributor.authorUndurraga Fourcade, Juan Pablo-
dc.contributor.authorGoikolea, José Manuel-
dc.contributor.authorAmann, Benedikt L.-
dc.contributor.authorCarvalho, André F.-
dc.contributor.authorVieta i Pascual, Eduard, 1963--
dc.description.abstractBackground: Schizoaffective disorder, bipolar type (SAD) and bipolar disorder I (BD) present a large clinical overlap. In a 1-year follow-up, we aimed to evaluate days to hospitalization (DTH) and predictors of relapse in a SAD-BD cohort of patients. Methods: A 1-year, prospective, naturalistic cohort study considering DTH as primary outcome and incidence of direct and indirect measures of psychopathological compensation as secondary outcomes. Kaplan-Meyer survival analysis with Log-rank Mantel-Cox test compared BD/SAD subgroups as to DTH. After bivariate analyses, Cox regression was performed to assess covariates possibly associated with DTH in diagnostic subgroups. Results: Of 836 screened patients, 437 were finally included (SAD = 105; BD = 332). Relapse rates in the SAD sample was n = 26 (24.8%) vs. n = 41 (12.3%) in the BD sample (p = 0.002). Mean ± SD DTH were 312.16 ± 10.6 (SAD) vs. 337.62 ± 4.4 (BD) days (p = 0.002). Patients with relapses showed more frequent suicide acts, violent behaviors, and changes in pharmacological treatments (all p < 0.0005) in comparison to patients without relapse. Patients without relapses had significantly higher mean number of treatments at T0 (p = 0.010). Cox regression model relating the association between diagnosis and DTH revealed that BD had higher rates of suicide attempts (HR = 13.0, 95%CI = 4.0-42.0, p < 0.0005), whereas SAD had higher rates of violent behavior during psychotic episodes (HR = 12.0, 95%CI = .3.3-43.5, p > 0.0005). Conclusions: SAD patients relapse earlier with higher hospitalization rates and violent behavior during psychotic episodes whereas bipolar patients have more suicide attempts. Psychiatric/psychological follow-up visits may delay hospitalizations by closely monitoring symptoms of self- and hetero-aggression.-
dc.format.extent8 p.-
dc.publisherCambridge University Press-
dc.relation.isformatofReproducció del document publicat a:
dc.relation.ispartofEuropean Psychiatry, 2019, vol. 61, p. 1-8-
dc.rights(c) Elsevier Masson SAS, 2019-
dc.subject.classificationTrastorn bipolar-
dc.subject.otherManic-depressive illness-
dc.titleA 12-month prospective study on the time to hospitalization and clinical management of a cohort of bipolar type I and schizoaffective bipolar patients-
Appears in Collections:Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)
Articles publicats en revistes (Medicina)

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