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http://hdl.handle.net/2445/179075
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DC Field | Value | Language |
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dc.contributor.author | Murru, Andrea | - |
dc.contributor.author | Verdolini, Norma | - |
dc.contributor.author | Anmella, Gerard | - |
dc.contributor.author | Pacchiarotti, Isabella | - |
dc.contributor.author | Samalin, Ludovic | - |
dc.contributor.author | Aedo, Alberto | - |
dc.contributor.author | Undurraga Fourcade, Juan Pablo | - |
dc.contributor.author | Goikolea, José Manuel | - |
dc.contributor.author | Amann, Benedikt L. | - |
dc.contributor.author | Carvalho, André F. | - |
dc.contributor.author | Vieta i Pascual, Eduard, 1963- | - |
dc.date.accessioned | 2021-07-14T14:41:35Z | - |
dc.date.available | 2021-07-14T14:41:35Z | - |
dc.date.issued | 2019-06-28 | - |
dc.identifier.issn | 0924-9338 | - |
dc.identifier.uri | http://hdl.handle.net/2445/179075 | - |
dc.description.abstract | Background: Schizoaffective disorder, bipolar type (SAD) and bipolar disorder I (BD) present a large clinical overlap. In a 1-year follow-up, we aimed to evaluate days to hospitalization (DTH) and predictors of relapse in a SAD-BD cohort of patients. Methods: A 1-year, prospective, naturalistic cohort study considering DTH as primary outcome and incidence of direct and indirect measures of psychopathological compensation as secondary outcomes. Kaplan-Meyer survival analysis with Log-rank Mantel-Cox test compared BD/SAD subgroups as to DTH. After bivariate analyses, Cox regression was performed to assess covariates possibly associated with DTH in diagnostic subgroups. Results: Of 836 screened patients, 437 were finally included (SAD = 105; BD = 332). Relapse rates in the SAD sample was n = 26 (24.8%) vs. n = 41 (12.3%) in the BD sample (p = 0.002). Mean ± SD DTH were 312.16 ± 10.6 (SAD) vs. 337.62 ± 4.4 (BD) days (p = 0.002). Patients with relapses showed more frequent suicide acts, violent behaviors, and changes in pharmacological treatments (all p < 0.0005) in comparison to patients without relapse. Patients without relapses had significantly higher mean number of treatments at T0 (p = 0.010). Cox regression model relating the association between diagnosis and DTH revealed that BD had higher rates of suicide attempts (HR = 13.0, 95%CI = 4.0-42.0, p < 0.0005), whereas SAD had higher rates of violent behavior during psychotic episodes (HR = 12.0, 95%CI = .3.3-43.5, p > 0.0005). Conclusions: SAD patients relapse earlier with higher hospitalization rates and violent behavior during psychotic episodes whereas bipolar patients have more suicide attempts. Psychiatric/psychological follow-up visits may delay hospitalizations by closely monitoring symptoms of self- and hetero-aggression. | - |
dc.format.extent | 8 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Cambridge University Press | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1016/j.eurpsy.2019.06.001 | - |
dc.relation.ispartof | European Psychiatry, 2019, vol. 61, p. 1-8 | - |
dc.relation.uri | https://doi.org/10.1016/j.eurpsy.2019.06.001 | - |
dc.rights | (c) Elsevier Masson SAS, 2019 | - |
dc.source | Articles publicats en revistes (Medicina) | - |
dc.subject.classification | Trastorn bipolar | - |
dc.subject.classification | Agressivitat | - |
dc.subject.other | Manic-depressive illness | - |
dc.subject.other | Aggressiveness | - |
dc.title | A 12-month prospective study on the time to hospitalization and clinical management of a cohort of bipolar type I and schizoaffective bipolar patients | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 690570 | - |
dc.date.updated | 2021-07-14T14:41:36Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 31255957 | - |
Appears in Collections: | Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) Articles publicats en revistes (Medicina) |
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File | Description | Size | Format | |
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690570.pdf | 711.18 kB | Adobe PDF | View/Open |
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