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Title: Sleep duration and napping in relation to colorectal and gastric cancer in the MCC-Spain study
Author: Papantoniou, Kyriaki
Castaño Vinyals, Gemma
Espinosa, Ana
Turner, Michelle C.
Martín Sánchez, Vicente
Casabonne, Delphine
Aragonés, Nuria
Gómez Acebo, Inés
Ardanaz, Eva
Jimenez Moleon, Jose Juan
Amiano, Pilar
Molina Barceló, Ana
Alguacil, Juan
Fernández Tardón, Guillermo
Huerta, José María
Hernández Segura, Natalia
Perez Gomez, Beatriz
Llorca, Javier
Vidán Alli, Juana
Olmedo Requena, Rocıo
Gil, Leire
Castañon López, Carmen
Pollan, Marina
Kogevinas, Manolis
Moreno Aguado, Víctor
Keywords: Càncer colorectal
Factors de risc en les malalties
Cáncer gastrointestinal
Colorectal cancer
Risk factors in diseases
Gastrointestinal cancer
Issue Date: 3-Jun-2021
Publisher: Springer Science and Business Media LLC
Abstract: Sleep duration is a novel and potentially modifiable risk factor for cancer. We evaluated the association of self-reported sleep duration and daytime napping with odds of colorectal and gastric cancer. We included 2008 incident colorectal cancer cases, 542 gastric cancer cases and 3622 frequency-matched population controls, recruited in the MCC-Spain case-control study (2008-2013). Sleep information, socio-demographic and lifestyle characteristics were obtained through personal interviews. Multivariable adjusted logistic regression models were used to estimate odds ratios (OR) with 95% confidence intervals (CI) for cancer, across categories of sleep duration (≤ 5, 6, 7, 8, ≥ 9 hours/day), daytime napping frequency (naps/week) and duration (minutes/nap). Compared to 7 hours of sleep, long sleep was associated with increased odds of colorectal (OR≥9 hours: 1.59; 95%CI 1.30-1.94) and gastric cancer (OR≥9 hours: 1.95; 1.37-2.76); short sleep was associated with increased odds of gastric cancer (OR≤5 hours: 1.32; 0.93-1.88). Frequent and long daytime naps increased the odds of colorectal (OR6-7 naps/week, ≥30 min: 1.32; 1.14-1.54) and gastric cancer (OR6-7 naps/week, ≥30 min: 1.56; 1.21-2.02). Effects of short sleep and frequent long naps were stronger among participants with night shift-work history. Sleep and circadian disruption may jointly play a role in the etiology of colorectal and gastric cancer.
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It is part of: Scientific Reports, 2021, vol. 11, num. 11822
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ISSN: 2045-2322
Appears in Collections:Articles publicats en revistes (Ciències Clíniques)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
Articles publicats en revistes (ISGlobal)

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