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http://hdl.handle.net/2445/179215
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DC Field | Value | Language |
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dc.contributor.author | Roy Vallejo, Emilia | - |
dc.contributor.author | Sánchez Purificación, Aquilino | - |
dc.contributor.author | Torres Peña, José | - |
dc.contributor.author | Sánchez Moreno, Beatriz | - |
dc.contributor.author | Arnalich Fernández, Francisco | - |
dc.contributor.author | García Blanco, María | - |
dc.contributor.author | López Miranda, José | - |
dc.contributor.author | Romero Cabrera, Juan | - |
dc.contributor.author | Herrero Gil, Carmen | - |
dc.contributor.author | Bascunana, José | - |
dc.contributor.author | Rubio-Rivas, Manuel | - |
dc.contributor.author | Pintos Otero, Sara | - |
dc.contributor.author | Martínez Sempere, Verónica | - |
dc.contributor.author | Ballano Rodríguez-Solís, Jesús | - |
dc.contributor.author | Gil Sánchez, Ricardo | - |
dc.contributor.author | Luque del Pino, Jairo | - |
dc.contributor.author | González Noya, Amara | - |
dc.contributor.author | Navas Alcántara, María | - |
dc.contributor.author | Cortés Rodríguez, Begoña | - |
dc.contributor.author | Alcalá, José | - |
dc.contributor.author | Suárez Lombraña, Ana | - |
dc.contributor.author | Andrés Soler, Jorge | - |
dc.contributor.author | Gómez Huelgas, Ricardo | - |
dc.contributor.author | Casas Rojo, José | - |
dc.contributor.author | Millán Núñez-Cortés, Jesús | - |
dc.contributor.author | SEMI-COVID-19 Network | - |
dc.date.accessioned | 2021-07-19T09:11:19Z | - |
dc.date.available | 2021-07-19T09:11:19Z | - |
dc.date.issued | 2021-06-15 | - |
dc.identifier.issn | 2077-0383 | - |
dc.identifier.uri | http://hdl.handle.net/2445/179215 | - |
dc.description.abstract | Our main aim was to describe the effect on the severity of ACEI (angiotensin-converting enzyme inhibitor) and ARB (angiotensin II receptor blocker) during COVID-19 hospitalization. A retrospective, observational, multicenter study evaluating hospitalized patients with COVID-19 treated with ACEI/ARB. The primary endpoint was the incidence of the composite outcome of prognosis (IMV (invasive mechanical ventilation), NIMV (non-invasive mechanical ventilation), ICU admission (intensive care unit), and/or all-cause mortality). We evaluated both outcomes in patients whose treatment with ACEI/ARB was continued or withdrawn. Between February and June 2020, 11,205 patients were included, mean age 67 years (SD = 16.3) and 43.1% female; 2162 patients received ACEI/ARB treatment. ACEI/ARB treatment showed lower all-cause mortality (p < 0.0001). Hypertensive patients in the ACEI/ARB group had better results in IMV, ICU admission, and the composite outcome of prognosis (p < 0.0001 for all). No differences were found in the incidence of major adverse cardiovascular events. Patients previously treated with ACEI/ARB continuing treatment during hospitalization had a lower incidence of the composite outcome of prognosis than those whose treatment was withdrawn (RR 0.67, 95%CI 0.63-0.76). ARB was associated with better survival than ACEI (HR 0.77, 95%CI 0.62-0.96). ACEI/ARB treatment during COVID-19 hospitalization was associated with protection on mortality. The benefits were greater in hypertensive, those who continued | - |
dc.format.extent | 13 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | MDPI AG | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.3390/jcm10122642 | - |
dc.relation.ispartof | Journal of Clinical Medicine, 2021, vol. 10, num. 12, p. 2642 | - |
dc.relation.uri | https://doi.org/10.3390/jcm10122642 | - |
dc.rights | cc by (c) Roy Vallejo, Emilia et al., 2021 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.source | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) | - |
dc.subject.classification | COVID-19 | - |
dc.subject.classification | Hospitals | - |
dc.subject.classification | Pacients hospitalitzats | - |
dc.subject.classification | Pronòstic mèdic | - |
dc.subject.other | COVID-19 | - |
dc.subject.other | Hospitals | - |
dc.subject.other | Hospital patients | - |
dc.subject.other | Prognosis | - |
dc.title | Angiotensin-Converting Enzyme Inhibitors and Angiotensin Receptor Blockers Withdrawal Is Associated with Higher Mortality in Hospitalized Patients with COVID-19 | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.date.updated | 2021-07-16T07:54:03Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
Files in This Item:
File | Description | Size | Format | |
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jcm-10-02642-v3.pdf | 3.97 MB | Adobe PDF | View/Open |
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