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Title: Differences between the child and adult brain in the local functional structure of the cerebral cortex
Author: Pujol, Jesus
Blanco Hinojo, Laura
Macia, Didac
Martínez Vilavella, Gerard
Deus, Joan
Pérez Sola, Víctor
Cardoner, N. (Narcís)
Soriano Mas, Carles
Sunyer, Jordi
Keywords: Evolució del cervell
Escorça cerebral
Evolution of the brain
Cerebral cortex
Issue Date: 1-Jul-2021
Publisher: Elsevier BV
Abstract: Imaging studies on neuronal network formation provide relevant information as to how the brain matures during adolescence. We used a novel imaging approach combining well-established MRI measures of local functional connectivity that jointly provide qualitatively different information relating to the functional structure of the cerebral cortex. To investigate the adolescent transition into adulthood, we comparatively assessed 169 preadolescents aged 8-12 years and 121 healthy adults. Whole-brain functional connectivity maps were generated using multi-distance measures of intracortical neural activity coupling defined within iso-distant local areas. Such Iso-Distant Average Correlation (IDAC) measures therefore represent the average temporal correlation of a given brain unit, or voxel, with other units situated at increasingly separated iso-distant intervals. The results indicated that between-group differences in the functional structure of the cerebral cortex are extensive and implicate part of the lateral prefrontal cortex, a medial frontal/anterior cingulate region, the superior parietal lobe extending to the somatosensory strip and posterior cingulate cortex, and local connections within the visual cortex, hippocampus, amygdala and insula. We thus provided detail of the cerebral cortex functional structure maturation during the transition to adulthood, which may serve to establish more accurate links between adolescent performance gains and cerebral cortex maturation. Remarkably, our study provides new information as to the cortical maturation processes in prefrontal areas relevant to executive functioning and rational learning, medial frontal areas playing an active role in the cognitive appraisal of emotion and anxiety, and superior parietal cortices strongly associated with bodily self-consciousness in the context of body image formation.
Note: Reproducció del document publicat a:
It is part of: NeuroImage, 2021, vol. 237, num. 118150
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ISSN: 1053-8119
Appears in Collections:Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
Articles publicats en revistes (ISGlobal)

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