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http://hdl.handle.net/2445/179296
Title: | Positive impact of a faecal-based screening programme on colorectal cancer mortality risk |
Author: | Ibáñez Sanz, Gemma Milà, Núria Vidal Lancis, Maria Carmen Rocamora, Judith Moreno Aguado, Víctor Sanz Pamplona, Rebeca García Martínez, Montserrat MSIC-SC Research Group |
Keywords: | Càncer colorectal Cribratge Mortalitat Colorectal cancer Medical screening Mortality |
Issue Date: | 30-Jun-2021 |
Publisher: | Public Library of Science (PLoS) |
Abstract: | Introduction The effectiveness of colorectal cancer (CRC) screening programs is directly related to participation and the number of interval CRCs. The objective was to analyse specific-mortality in a cohort of individuals invited to a CRC screening program according to type of CRC diagnosis (screen-detected cancers, interval cancers, and cancers among the non-uptake group). Material and methods Retrospective cohort that included invitees aged 50-69 years of a CRC screening program (target population of 85,000 people) in Catalonia (Spain) from 2000-2015 with mortality follow-up until 2020. A screen-detected CRC was a cancer diagnosed after a positive faecal occult blood test (guaiac or immunochemical); an interval cancer was a cancer diagnosed after a negative test result and before the next invitation to the program (<= 24 months); a non-uptake cancer was a cancer in subjects who declined screening. Results A total of 624 people were diagnosed with CRC (n = 265 screen-detected, n = 103 interval cancers, n = 256 non-uptake). In the multivariate analysis, we observed a 74% increase in mortality rate in the group with interval CRC compared to screen-detected CRC adjusted for age, sex, location and stage (HR: 1.74%, 95% CI:1.08-2.82, P = 0.02). These differences were found even when we restricted for advanced-cancers participants. In the stratified analysis for type of faecal occult blood test, a lower mortality rate was only observed among FIT screen-detected CRCs. Conclusion CRC screening with the FIT was associated with a significant reduction in CRC mortality. |
Note: | Reproducció del document publicat a: https://doi.org/10.1371/journal.pone.0253369 |
It is part of: | PLOS ONE, 2021, vol.16, num. 6, p. e0253369 |
URI: | http://hdl.handle.net/2445/179296 |
Related resource: | https://doi.org/10.1371/journal.pone.0253369 |
ISSN: | 1932-6203 |
Appears in Collections: | Articles publicats en revistes (Ciències Clíniques) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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