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http://hdl.handle.net/2445/179303
Title: | Epigenetic differences arise during the lifetime of monozygotic twins |
Author: | Fraga, Mario F. Ballestar Tarín, Esteban Paz, Maria F. Ropero, Santiago Setién, Fernando Ballester Palacios, M. L. (Maria Lluïsa) Heine-Suñer, Damia Cigudosa, Juan Cruz Urioste, Miguel Benitez, Javier Boix-Chornet, Manuel Sánchez-Aguilera, Abel Ling, Charlotte Carlsson, Emma Poulsen, Pernille Vaag, Allan Stephan, Zarko Spector, Tim D. Wu, Yue-Zhong Plass, Christoph Esteller, Manel |
Keywords: | ADN Expressió gènica Histones Fenotip Bessons DNA Gene expression Histones Phenotype Twins |
Issue Date: | 26-Jul-2005 |
Publisher: | National Academy of Sciences |
Abstract: | Monozygous twins share a common genotype. However, most monozygotic twin pairs are not identical; several types of phenotypic discordance may be observed, such as differences in susceptibilities to disease and a wide range of anthropomorphic features. There are several possible explanations for these observations, but one is the existence of epigenetic differences. To address this issue, we examined the global and locus-specific differences in DNA methylation and histone acetylation of a large cohort of monozygotic twins. We found that, although twins are epigenetically indistinguishable during the early years of life, older monozygous twins exhibited remarkable differences in their overall content and genomic distribution of 5-methylcytosine DNA and histone acetylation, affecting their gene-expression portrait. These findings indicate how an appreciation of epigenetics is missing from our understanding of how different phenotypes can be originated from the same genotype. |
Note: | Reproducció del document publicat a: https://doi.org/10.1073/pnas.0500398102 |
It is part of: | Proceedings of the National Academy of Sciences of the United States of America - PNAS, 2005, vol. 102, num. 30, p. 10604-10609 |
URI: | http://hdl.handle.net/2445/179303 |
Related resource: | https://doi.org/10.1073/pnas.0500398102 |
ISSN: | 0027-8424 |
Appears in Collections: | Articles publicats en revistes (Ciències Fisiològiques) |
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