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http://hdl.handle.net/2445/179328
Title: | Risk factors for unfavorable outcome and impact of early post-transplant infection in solid organ recipients with COVID-19: A prospective multicenter cohort study |
Author: | Salto Alejandre, Sonsoles Jiménez Jorge, Silvia Sabé, Nuria Ramos Martínez, Antonio Linares, Laura Valerio, Maricela Martín Dávila, Pilar Fernández Ruiz, Mario Fariñas, María Carmen Blanes Juliá, Marino Vidal, Elisa Palacios Baena, Zaira R. Hernández Gallego, Román Carratalà, Jordi Calderón Parra, Jorge Marcos, Ma. Angeles Muñoz, Patricia Fortún, Jesús Aguado, José María Arnaiz Revillas, Francisco Blanes Hernández, Rosa Torre Cisneros, Julián de la López Cortés, Luis Eduardo García de Vinuesa Calvo, Elena Rosso, Clara M. Pachón, Jerónimo Sánchez Céspedes, Javier Cordero, Elisa The Covidsot Working Team |
Keywords: | COVID-19 Factors de risc en les malalties Trasplantament d'òrgans SARS-CoV-2 COVID-19 Risk factors in diseases Transplantation of organs SARS-CoV-2 |
Issue Date: | 29-Apr-2021 |
Publisher: | Public Library of Science (PLoS) |
Abstract: | The aim was to analyze the characteristics and predictors of unfavorable outcomes in solid organ transplant recipients (SOTRs) with COVID-19. We conducted a prospective observational cohort study of 210 consecutive SOTRs hospitalized with COVID-19 in 12 Spanish centers from 21 February to 6 May 2020. Data pertaining to demographics, chronic underlying diseases, transplantation features, clinical, therapeutics, and complications were collected. The primary endpoint was a composite of intensive care unit (ICU) admission and/or death. Logistic regression analyses were performed to identify the factors associated with these unfavorable outcomes. Males accounted for 148 (70.5%) patients, the median age was 63 years, and 189 (90.0%) patients had pneumonia. Common symptoms were fever, cough, gastrointestinal disturbances, and dyspnea. The most used antiviral or host-targeted therapies included hydroxychloroquine 193/200 (96.5%), lopinavir/ritonavir 91/200 (45.5%), and tocilizumab 49/200 (24.5%). Thirty-seven (17.6%) patients required ICU admission, 12 (5.7%) suffered graft dysfunction, and 45 (21.4%) died. A shorter interval between transplantation and COVID-19 diagnosis had a negative impact on clinical prognosis. Four baseline features were identified as independent predictors of intensive care need or death: advanced age, high respiratory rate, lymphopenia, and elevated level of lactate dehydrogenase. In summary, this study presents comprehensive information on characteristics and complications of COVID-19 in hospitalized SOTRs and provides indicators available upon hospital admission for the identification of SOTRs at risk of critical disease or death, underlining the need for stringent preventative measures in the early post-transplant period. |
Note: | Reproducció del document publicat a: https://doi.org/10.1371/journal.pone.0250796 |
It is part of: | PLOS ONE, 2021, vol. 16, num. 4, p. e0250796 |
URI: | http://hdl.handle.net/2445/179328 |
Related resource: | https://doi.org/10.1371/journal.pone.0250796 |
ISSN: | 1932-6203 |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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