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DC Field | Value | Language |
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dc.contributor.author | Martinez Valenzuela, Laura | - |
dc.contributor.author | Draibe, Juliana | - |
dc.contributor.author | Bestard, Oriol | - |
dc.contributor.author | Fulladosa, Xavier | - |
dc.contributor.author | Gómez Preciado, Francisco | - |
dc.contributor.author | Antón, Paula | - |
dc.contributor.author | Nadal, Ernest | - |
dc.contributor.author | Jové, Maria | - |
dc.contributor.author | Cruzado, Josep Maria | - |
dc.contributor.author | Torras, Juan | - |
dc.date.accessioned | 2021-07-22T10:04:29Z | - |
dc.date.available | 2021-07-22T10:04:29Z | - |
dc.date.issued | 2021-07-04 | - |
dc.identifier.issn | 2077-0383 | - |
dc.identifier.uri | http://hdl.handle.net/2445/179335 | - |
dc.description.abstract | Background: Acute tubulointerstitial nephritis (ATIN) diagnosis lays on histological assessment through a kidney biopsy, given the absence of accurate non-invasive biomarkers. The aim of this study was to evaluate the accuracy of different urinary inflammation-related cytokines for the diagnostic of ATIN and its distinction from acute tubular necrosis (ATN). Methods: We included 33 patients (ATIN (n = 21), ATN (n = 12)), and 6 healthy controls (HC). We determined the urinary levels of 10 inflammation-related cytokines using a multiplex bead-based Luminex assay at the time of biopsy and after therapy, and registered main clinical, analytical and histological data. Results: At the time of biopsy, urinary levels of I-TAC/CXCL11, CXCL10, IL-6, TNF alpha and MCP-1 were significantly higher in ATIN compared to HC. A positive correlation between the extent of the tubulointerstitial cellular infiltrates in kidney biopsies and the urinary concentration of I-TAC/CXCL11, MIG/CXCL9, CXCL10, IL17, IFN alpha, MCP1 and EGF was observed. Notably, I-TAC/CXCL11, IL-6 and MCP-1 were significantly higher in ATIN than in ATN, with I-TAC/CXCL11 as the best discriminative classifier AUC (0.77, 95% CI 0.57-0.95, p = 0.02). A combinatory model of these three urinary cytokines increased the accuracy in the distinction of ATIN/ATN compared to the individual biomarkers. The best model resulted when combining the three cytokines with blood eosinophil and urinary leukocyte counts (LR = 9.76). Follow-up samples from 11ATIN patients showed a significant decrease in I-TAC/CXCL11, MIG/CXCL9 and CXCL10 levels. Conclusions: Urinary I-TAC/CXCL11, CXCL10, IL6 and MCP-1 levels accurately distinguish patients developing ATIN from ATN and healthy individuals and may serve as novel non-invasive biomarkers in this disease. | - |
dc.format.extent | 13 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | MDPI AG | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.3390/jcm10132986 | - |
dc.relation.ispartof | Journal of Clinical Medicine, 2021, vol. 10, num. 13, p. 2986 | - |
dc.relation.uri | https://doi.org/10.3390/jcm10132986 | - |
dc.rights | cc by (c) Martinez Valenzuela, Laura et al., 2021 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.source | Articles publicats en revistes (Ciències Clíniques) | - |
dc.subject.classification | Malalties del ronyó | - |
dc.subject.classification | Marcadors bioquímics | - |
dc.subject.classification | Citoquines | - |
dc.subject.other | Kidney diseases | - |
dc.subject.other | Biochemical markers | - |
dc.title | Urinary Cytokines Reflect Renal Inflammation in Acute Tubulointerstitial Nephritis: A Multiplex Bead-Based Assay Assessment | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 716080 | - |
dc.date.updated | 2021-07-22T08:57:47Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
Appears in Collections: | Articles publicats en revistes (Ciències Clíniques) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
Files in This Item:
File | Description | Size | Format | |
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jcm-10-02986.pdf | 1.44 MB | Adobe PDF | View/Open |
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