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Title: The TGF-β Pathway: A Pharmacological Target in Hepatocellular Carcinoma?
Author: Gonzalez Sanchez, Ester
Vaquero, Javier
Férnandez Barrena, Maite G.
Lasarte, Juan José
Avila, Matías A.
Sarobe, Pablo
Reig, María
Calvo, Mariona
Fabregat, Isabel
Keywords: Marcadors bioquímics
Càncer de fetge
Biochemical markers
Liver cancer
Issue Date: 29-Jun-2021
Publisher: MDPI AG
Abstract: Transforming Growth Factor-beta (TGF-β) superfamily members are essential for tissue homeostasis and consequently, dysregulation of their signaling pathways contributes to the development of human diseases. In the liver, TGF-β signaling participates in all the stages of disease progression from initial liver injury to hepatocellular carcinoma (HCC). During liver carcinogenesis, TGF-β plays a dual role on the malignant cell, behaving as a suppressor factor at early stages, but contributing to later tumor progression once cells escape from its cytostatic effects. Moreover, TGF-β can modulate the response of the cells forming the tumor microenvironment that may also contribute to HCC progression, and drive immune evasion of cancer cells. Thus, targeting the TGF-β pathway may constitute an effective therapeutic option for HCC treatment. However, it is crucial to identify biomarkers that allow to predict the response of the tumors and appropriately select the patients that could benefit from TGF-β inhibitory therapies. Here we review the functions of TGF-β on HCC malignant and tumor microenvironment cells, and the current strategies targeting TGF-β signaling for cancer therapy. We also summarize the clinical impact of TGF-β inhibitors in HCC patients and provide a perspective on its future use alone or in combinatorial strategies for HCC treatment.
Note: Reproducció del document publicat a:
It is part of: Cancers, 2021, vol. 13, issue. 13, p. 3248
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ISSN: 2072-6694
Appears in Collections:Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)
Articles publicats en revistes (Ciències Fisiològiques)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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