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Title: Fluorogenic Trp(redBODIPY) cyclopeptide targeting keratin 1 for imaging of aggressive carcinomas
Author: Subirós Funosas, Ramon
Cheuk Lam Ho, Vivian
Barth, Nicole D.
Mendive Tapia, Lorena
Pappalardo, Morena
Barril Alonso, Xavier
Ma, Ruoyu
Zhang, Cheng-Bin
Qian, Bin-Zhi
Sintes Marcos, Miquel
Ghashghaei, Ouldouz
Lavilla Grífols, Rodolfo
Vendrell, Marc
Keywords: Pèptids
Amino acids
Issue Date: 20-Jan-2020
Publisher: Royal Society of Chemistry
Abstract: Keratin 1 (KRT1) is overexpressed in squamous carcinomas and associated with aggressive pathologies in breast cancer. Herein we report the design and preparation of the first Trp-based red fluorogenic amino acid, which is synthetically accessible in a few steps and displays excellent photophysical properties, and its application in a minimally-disruptive labelling strategy to prepare a new fluorogenic cyclopeptide for imaging of KRT1+ cells in whole intact tumour tissues.
Note: Reproducció del document publicat a:
It is part of: Chemical Science, 2020, vol. 11, p. 1368-1374
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ISSN: 2041-6520
Appears in Collections:Articles publicats en revistes (Farmàcia, Tecnologia Farmacèutica i Fisicoquímica)
Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)

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