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http://hdl.handle.net/2445/179405
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DC Field | Value | Language |
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dc.contributor.author | Adelfinskaya, O. | - |
dc.contributor.author | Terrazas Martínez, Montserrat | - |
dc.contributor.author | Froeyen, M. | - |
dc.contributor.author | Marlière, P. | - |
dc.contributor.author | Nauwelaerts, K. | - |
dc.contributor.author | Herdewijn, P. | - |
dc.date.accessioned | 2021-07-27T12:24:35Z | - |
dc.date.available | 2021-07-27T12:24:35Z | - |
dc.date.issued | 2007-07-25 | - |
dc.identifier.issn | 0305-1048 | - |
dc.identifier.uri | http://hdl.handle.net/2445/179405 | - |
dc.description.abstract | Some selected amino acids, in particular L-aspartic acid (L-Asp) and L-histidine (L-His), can function as leaving group during polymerase-catalyzed incorporation of deoxyadenosine monophosphate (dAMP) in DNA. Although L-Asp-dAMP and L-His-dAMP bind, most probably, in a different way in the active site of the enzyme, aspartic acid and histidine can be considered as mimics of the pyrophosphate moiety of deoxyadenosine triphosphate. L-Aspartic acid is more efficient than D-aspartic acid as leaving group. Such P-N conjugates of amino acids and deoxynucleotides provide a novel experimental ground for diversifying nucleic acid metabolism in the field of synthetic biology. | - |
dc.format.extent | 13 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Oxford University Press | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1093/nar/gkm498 | - |
dc.relation.ispartof | Nucleic Acids Research, 2007, vol. 35, num. 15, p. 5060-5072 | - |
dc.relation.uri | https://doi.org/10.1093/nar/gkm498 | - |
dc.rights | cc-by-nc (c) Adelfinskaya, O. et al., 2007 | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc/4.0/ | - |
dc.source | Articles publicats en revistes (Química Inorgànica i Orgànica) | - |
dc.subject.classification | ADN | - |
dc.subject.classification | Aminoàcids | - |
dc.subject.classification | Polímers | - |
dc.subject.other | DNA | - |
dc.subject.other | Amino acids | - |
dc.subject.other | Polymers | - |
dc.title | Polymerase-catalyzed synthesis of DNA from phosphoramidate conjugates of deoxynucleotides and amino acids | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 713445 | - |
dc.date.updated | 2021-07-27T12:24:35Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 17652326 | - |
Appears in Collections: | Articles publicats en revistes (Química Inorgànica i Orgànica) |
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713445.pdf | 626.99 kB | Adobe PDF | View/Open |
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