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Title: Evolution of cervical cytologic changes among HIV-infected women with normal cytology in the HAART era.
Author: Videla, Sebas
Sirera, Guillem
López-Blázquez, Raquel
Llatjos, Mariona
Tarrats, Antoni
Castellà, Eva
Grane, Nuria
Alcalde, Carme
Tural, Cristina
Rey-Joly, Celestino
Clotet i Sala, Bonaventura
Keywords: Antiretrovirals
Coll uterí
VIH (Virus)
Antiretroviral agents
Cervix uteri
HIV (Viruses)
Issue Date: 1-Aug-2007
Publisher: Mary Ann Liebert
Abstract: The influence of HAART on the evolution to cervical squamous intraepithelial lesions (SIL) among HIV(+) women with a normal cytological test in the HAART era was studied. A retrospective cohort study (1997-2005) of HIV-infected women treated with HAART was conducted. Those with a normal cervical cytology (Papanicolaou test) and at least one subsequent test were included. Survival (time until diagnosis of SIL), univariate, and multivariate analyses were performed. A total of 133 HIV-infected patients treated with HAART were included. The incidence of SIL was 35% (47 patients). SIL was diagnosed in 36 of 110 (33%) patients with a baseline and final immunological status of >200 CD4 cells/microl and in 6 of 9 (67%) patients with a baseline and final immunological status of < or =200 CD4 (OR: 0.24, 95% CI: 0.06-1.03, p = 0.041). SIL was diagnosed in 10 of 60 (17%) patients with an undetectable baseline and final HIV viral load and in 36 of 70 (51%) patients with a detectable HIV viral load (OR: 0.19, 95% CI: 0.07-0.46, p < 0.001). A high incidence of SIL (cancer precursor lesions) was observed among HIV(+) women without a background of cervical pathology. The effect of HAART on the control of HIV replication and of immunological status (>200 CD4) through the follow-up was associated with a reduction of SIL.
Note: Reproducció del document publicat a:
It is part of: Aids Research and Human Retroviruses, 2007, vol. 23, num. 8, p. 965-971
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ISSN: 0889-2229
Appears in Collections:Articles publicats en revistes (Patologia i Terapèutica Experimental)

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