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http://hdl.handle.net/2445/179621
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DC Field | Value | Language |
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dc.contributor.author | Steward, Trevor | - |
dc.contributor.author | Martínez Zalacaín, Ignacio | - |
dc.contributor.author | Mestre-Bach, Gemma | - |
dc.contributor.author | Sánchez Zaplana, Isabel | - |
dc.contributor.author | Riesco, Nadine | - |
dc.contributor.author | Jiménez-Murcia, Susana | - |
dc.contributor.author | Fernández Formoso, Jose A. | - |
dc.contributor.author | Veciana de las Heras, Misericordia | - |
dc.contributor.author | Custal, Nuria | - |
dc.contributor.author | Menchón Magriñá, José Manuel | - |
dc.contributor.author | Soriano Mas, Carles | - |
dc.contributor.author | Fernández Aranda, Fernando | - |
dc.date.accessioned | 2021-08-04T12:13:13Z | - |
dc.date.available | 2021-08-04T12:13:13Z | - |
dc.date.issued | 2020-07-23 | - |
dc.identifier.issn | 0033-2917 | - |
dc.identifier.uri | http://hdl.handle.net/2445/179621 | - |
dc.description.abstract | Background: although deficits in affective processing are a core component of anorexia nervosa (AN), we lack a detailed characterization of the neurobiological underpinnings of emotion regulation impairment in AN. Moreover, it remains unclear whether these neural correlates scale with clinical outcomes. Methods: we investigated the neural correlates of negative emotion regulation in a sample of young women receiving day-hospital treatment for AN (n = 21) and healthy controls (n = 21). We aimed to determine whether aberrant brain activation patterns during emotion regulation predicted weight gain following treatment in AN patients and were linked to AN severity. To achieve this, participants completed a cognitive reappraisal paradigm during functional magnetic resonance imaging. Skin conductance response, as well as subjective distress ratings, were recorded to corroborate task engagement. Results: compared to controls, patients with AN showed reduced activation in the dorsolateral prefrontal cortex (dlPFC) during cognitive reappraisal [pFWE<0.05, threshold-free cluster enhancement (TFCE) corrected]. Importantly, psycho-physiological interaction analysis revealed reduced functional connectivity between the dlPFC and the amygdala in AN patients during emotion regulation (pFWE<0.05, TFCE corrected), and dlPFC-amygdala uncoupling was associated with emotion regulation deficits (r = -0.511, p = 0.018) and eating disorder severity (r = -0.565, p = .008) in the AN group. Finally, dlPFC activity positively correlated with increases in body mass index (r = 0.471, p = 0.042) and in body fat mass percentage (r = 0.605, p = 0.008) following 12 weeks of treatment. Conclusions: taken together, our findings indicate that individuals with AN present altered fronto-amygdalar response during cognitive reappraisal and that this response may serve as a predictor of response to treatment and be linked to clinical severity. | - |
dc.format.extent | 9 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Cambridge University Press | - |
dc.relation.isformatof | Versió postprint del document publicat a: https://doi.org/10.1017/S0033291720002457 | - |
dc.relation.ispartof | Psychological Medicine, 2020, vol. 23, p. 1-9 | - |
dc.relation.uri | https://doi.org/10.1017/S0033291720002457 | - |
dc.rights | (c) Cambridge University Press, 2020 | - |
dc.source | Articles publicats en revistes (Ciències Clíniques) | - |
dc.subject.classification | Anorèxia nerviosa | - |
dc.subject.classification | Trastorns de la conducta alimentària | - |
dc.subject.classification | Emocions | - |
dc.subject.other | Anorexia nervosa | - |
dc.subject.other | Eating disorders | - |
dc.subject.other | Emotions | - |
dc.title | Dorsolateral prefrontal cortex and amygdala function during cognitive reappraisal predicts weight restoration and emotion regulation impairment in anorexia nervosa | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/acceptedVersion | - |
dc.identifier.idgrec | 710349 | - |
dc.date.updated | 2021-08-04T12:13:13Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 32698931 | - |
Appears in Collections: | Articles publicats en revistes (Ciències Clíniques) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
Files in This Item:
File | Description | Size | Format | |
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710349.pdf | 338.72 kB | Adobe PDF | View/Open |
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